Evidence map›Paper›PMID 40742731›Full record

ArticleJMIR research protocols2025

Assessing Clinical Impressions of Early Warning Score Integration With the Rapid Response Team: Protocol for a Prospective Cohort Study.

Alexandre Tran, Rashi Ramchandani, Jamie Brehaut, Natasha Hudek, Jessica Haines, Irene Watpool, Rebecca Porteous, Dora Kusevic, Kirby Bucciero, Kwadwo Kyeremanteng and 11 more

Registry-linked trialAbstract readClinical Trial Protocol
In one paragraph

Article in JMIR research protocols, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05108376 (Feasibility and Initial Clinical Impressions of Predictive Monitoring Integrated With the RACE Team), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05108376 narecruitingnot on this map

Feasibility and Initial Clinical Impressions of Predictive Monitoring Integrated With the RACE Team

TypeinterventionalSponsorOttawa Hospital Research InstituteRan2023 to 2025Enrolled140ConditionsDeterioration, ClinicalArmsVisensia Safety Index (VSI)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Alexandre Tran *Division of General Surgery, Department of Surgery, Ottawa Hospital, Ottawa, ON, Canada.ORCID 0000-0002-3862-1676
Rashi Ramchandani *Department of Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.ORCID 0000-0002-6144-6423
Jamie BrehautMethodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.ORCID 0000-0002-4213-1143
Natasha HudekMethodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.ORCID 0000-0002-3486-7871
Jessica HainesDepartment of Critical Care, Ottawa Hospital, Ottawa, ON, Canada.ORCID 0009-0003-2535-4825
Irene WatpoolDepartment of Critical Care, Ottawa Hospital, Ottawa, ON, Canada.ORCID 0000-0001-7211-9586
Rebecca PorteousDepartment of Critical Care, Ottawa Hospital, Ottawa, ON, Canada.ORCID 0000-0003-2806-8974
Dora KusevicAcute Care Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.ORCID 0009-0006-9563-7427
Kirby BuccieroAcute Care Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.ORCID 0009-0001-2408-4806
Kwadwo KyeremantengDepartment of Critical Care, Ottawa Hospital, Ottawa, ON, Canada.ORCID 0000-0002-6836-2185
Michael HartwickDepartment of Critical Care, Ottawa Hospital, Ottawa, ON, Canada.ORCID 0000-0002-2888-6996
Kednapa ThavornMethodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.ORCID 0000-0003-4738-8447
Jonathan HooperDepartment of Critical Care, Ottawa Hospital, Ottawa, ON, Canada.ORCID 0000-0002-9525-2272
Dalibor KubelikDepartment of Critical Care, Ottawa Hospital, Ottawa, ON, Canada.ORCID 0009-0003-0000-1062
Christophe HerryAcute Care Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.ORCID 0000-0003-1863-5920
Nathan ScalesAcute Care Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.ORCID 0000-0002-9535-7138
Brett HryciwDepartment of Critical Care, Ottawa Hospital, Ottawa, ON, Canada.ORCID 0000-0002-4261-0208
Jad Abou-KhalilDivision of General Surgery, Department of Surgery, Ottawa Hospital, Ottawa, ON, Canada.ORCID 0000-0002-4818-0085
Jeffrey PerryAcute Care Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.ORCID 0000-0003-2134-9597
Christopher BredesonDivision of Hematology, Ottawa Hospital, Ottawa, ON, Canada.ORCID 0000-0002-9689-5114
Andrew SeelyDepartment of Critical Care, Ottawa Hospital, Ottawa, ON, Canada.ORCID 0000-0002-6459-8801

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe use of early warning scores (EWSs), which integrate real-time vital sign monitoring, can help rapid response teams (RRTs) proactively identify patients at risk of deterioration. However, existing EWSs demonstrate limited evidence for the reduction of clinically important adverse events. The Visensia Safety Index (VSI) is an EWS that combines heart rate, blood pressure, temperature, oxygen saturation, and respiration rate vital sign information to generate a VSI acuity score ranging from 0, signifying the lowest risk of deterioration, to 5, signifying highest risk of deterioration. Continuous monitoring of the risk of deterioration, with alerts triggered by a score of 3.0 or greater, prompts medical attention.

objectiveThis protocol outlines the methodology for assessing the feasibility of combining a portable continuous vital sign monitoring system (Masimo Root Monitor) with VSI monitoring to evaluate patients at high risk of acute deterioration at The Ottawa Hospital (TOH).

methodsThis 2-phase, prospective cohort study will be conducted at TOH. Patient participants will include adults (≥18 years) with high-risk conditions, such as those undergoing high-risk elective surgery, malignant hematology or oncology patients, and those admitted with infections. Exclusion criteria include patients receiving comfort care or those in specialized units requiring higher-level monitoring. Eligible patients will be monitored using the VSI with alerts to trigger rapid response team evaluation. In tandem, health care workers including physicians, nurses, and research staff who are involved in patient care and monitoring will be recruited for semistructured interviews. These interviews will explore health care providers' clinical impressions of the VSI as an EWS to identify barriers and enablers to implementation using the Consolidated Framework for Implementation Research. Interviews will assess impressions of the monitoring technology, clinical workflow challenges, and perceptions of implementation. Data analysis will involve directed content analysis of interview transcripts to identify barriers and drivers for successful implementation. Furthermore, the feasibility of the VSI will be assessed by evaluating the proportion of continuous data successfully collected and transmitted, the timeliness of VSI-triggered alerts and their communication to the RRT team, the regular updating of the predictive tool, the rate of reported VSI-triggered events, and the completion rates of study-related tasks by research and clinical staff.

resultsAs of April 2025, we can report that enrollment is complete, and analysis of the results is ongoing. Interviews are still being transcribed and analyzed. We anticipate submission for publication of the results of the study by the summer of 2025.

conclusionsThe execution of this prospective, mixed methods feasibility study requires a multidisciplinary effort. The study uses continuous vital sign monitoring, combined with prediction of deterioration risk, used to activate the RRT. Evaluating the feasibility and clinical impressions of this trial implementation is the first step in exploring monitoring-based predictive decision support.

trial registrationClinicalTrials.gov NCT05108376; https://clinicaltrials.gov/study/NCT05108376. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/65360.

Indexed as

Early Warning ScoreHospital Rapid Response TeamAdultClinical DeteriorationFeasibility StudiesHumansMonitoring, PhysiologicProspective StudiesVital Signscritical careearly warning scoreintensive care unitrapid response teamresuscitationVisensia safety index

Identifiers

PMID40742731
PMCPMC12355135

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.