Observational studyIndian pediatrics2025
Vasoactive-Inotropic Score (VIS) and Outcome of Children with Pediatric Septic Shock.
Observational study in Indian pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Procalcitonin kinetics in critically ill children: impact of continuous kidney replacement therapy modality and dose.Pediatric nephrology (Berlin, Germany) · 2026Observational
- Septic Cardiomyopathy: Age-Dependent Physiology and Hemodynamic Aspects-A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Aggregate Vasoactive Inotropic Score: A Step Forward in Pediatric Septic Shock.Indian pediatrics · 2025Article
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Authors and funding
3 authors.
Funding
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Abstract
objectiveTo assess the effectiveness of the vasoactive-inotropic score (VIS) in predicting outcomes for pediatric sepsis.
methodsA one-year prospective observational study in a tertiary level pediatric intensive care unit (PICU), enrolled children (1 month to 12 years) with fluid-refractory septic shock. VIS and aggregate VIS (AVIS) was calculated at 6, 12, 24, 48, 72, and 96 h post-hospitalization. The primary outcome assessed was mortality and secondary outcomes included duration of PICU stay, ventilation and inotrope support.
resultsNinety (64.4% male) patients with median (Q1, Q3) age of 24 [6, 60] months were enrolled. The median (Q1, Q3) duration of PICU stay (days) among survivors (n = 32) was significantly shorter 9 (7, 12) compared to non-survivors (n = 58) was 13 (9, 16) (P < 0.001). Significant correlations were found between AVIS at 96 h (AVIS96) and lactate levels (r = 0.79, P < 0.001), duration of inotrope support (r = 0.73, P < 0.001), and duration of ventilation (r = 0.69, P < 0.001). An AVIS96 cutoff of ≥ 25.4 showed high accuracy for mortality prediction (AUC 0.976, sensitivity 95%, specificity 90%), outperforming pSOFA and lactate levels.
conclusionVIS is a reliable predictor of outcomes in pediatric septic shock, with potential for early risk stratification. An AVIS96 cut-off value of 25.4 showed maximum diagnostic accuracy in terms of mortality prediction in this cohort.
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