Evidence map›Paper›PMID 40742618›Full record

ArticleMycopathologia2025

Serum Mannose-Binding Lectin Levels in Asthma and Allergic Bronchopulmonary Aspergillosis.

Inderpaul Singh Sehgal, Hansraj Choudhary, Valliappan Muthu, Sahajal Dhooria, Kuruswamy Thurai Prasad, Shivaprakash M Rudramurthy, Ashutosh Nath Aggarwal, Mandeep Garg, Arunaloke Chakrabarti, Ritesh Agarwal

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Article in Mycopathologia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Inderpaul Singh SehgalDepartment of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Hansraj ChoudharyDivision of Communicable Diseases, Indian Council of Medical Research (ICMR), New Delhi, India.
Valliappan MuthuDepartment of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Sahajal DhooriaDepartment of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Kuruswamy Thurai PrasadDepartment of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Shivaprakash M RudramurthyDepartment of Medical Microbiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Ashutosh Nath AggarwalDepartment of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Mandeep GargDepartment of Radiodiagnosis, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Arunaloke ChakrabartiDoodhadhari Burfani Hospital, Haridwar, Uttarakhand, India.
Ritesh AgarwalDepartment of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India. agarwal.ritesh@outlook.in.ORCID http://orcid.org/0000-0003-2547-7668

Funding

Indian Council of Medical Research 5/8/4-3/COPD/2019-NCD-I
6 · The paper itself

Abstract

Mannose-binding lectin (MBL) contributes to innate immunity against Aspergillus fumigatus. We assessed the role of reduced MBL levels in asthma patients with and without allergic bronchopulmonary aspergillosis (ABPA). In this prospective cross-sectional study, we enrolled 154 adults: 48 with asthma, 27 with Aspergillus-sensitized asthma (ASA, A. fumigatus-IgE ≥ 0.35 kUA/L), and 79 with ABPA. Serum MBL levels were quantified using enzyme-linked immunosorbent assay. Reduced MBL levels were defined using three thresholds (< 200, < 359, and < 500 ng/mL). The prevalence of reduced MBL levels did not differ significantly among the groups at any threshold. However, mean MBL levels were significantly lower in patients with ABPA (961 ng/mL) compared to asthma (1159 ng/mL) and ASA (1593 ng/mL; p = 0.048). Among ABPA patients, reduced MBL levels (≤ 359 ng/mL) were not associated with significant differences in clinical features, immunological markers, lung function, or radiology.

Indexed as

Aspergillosis, Allergic BronchopulmonaryAsthmaMannose-Binding LectinSerumAdultAgedAspergillus fumigatusCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayFemaleHumansMaleMiddle AgedProspective StudiesYoung AdultMannose-Binding LectinAspergillosisAsthmaBronchiectasisInnate immunityMBL

Identifiers

PMID40742618

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.