ArticleEuropean journal of nuclear medicine and molecular imaging2026
Cardiac mechanical synchrony couples with myocardial sympathetic innervation. A retrospective study with novel echocardiographic assessment in patients with
Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeLeft ventricular (LV) mechanical synchrony is essential for efficient cardiac function, and its disruption (dyssynchrony) negatively impacts outcomes, particularly in heart failure. Although sympathetic innervation modulates electrical activation and contraction timing, its relationship with mechanical synchrony is underexplored. This study aimed to assess their association using echocardiographic synchrony indices and
methodsWe retrospectively analyzed 208 patients who underwent both
resultsBoth synchrony indices significantly associated with late H/Mr, with AMP-sync showing superior model performance. The relationship followed a robust inverse-square pattern, independent of age, EF, and BMI. AMP-sync explained approximately 30% of the variance in late H/Mr, comparable to EF. Bootstrap validation confirmed the stability of the findings. No significant associations were found with early H/Mr or washout rate.
conclusionLV mechanical dyssynchrony is independently associated with reduced myocardial sympathetic innervation. The novel AMP-sync index outperformed SD-sync in predicting late H/Mr and may offer added value for patient stratification. External validation of AMP-sync in independent cohorts is warranted before routine clinical adoption.
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