ArticleCell biochemistry and biophysics2025
Revealing Lactiplantibacillus Plantarum K25 Derived (Z)-18-Octadec-9-Enolide in Modulating Aquaporin-8 in Colorectal Cancer by Bridging the Gut Microbiome and Membrane Biology.
Article in Cell biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Interpreting the Black Box: Interpretable Machine Learning and Systems Pharmacology in Small-Molecule Therapeutics.Pharmaceutics · 2026Review
- Enhancement of nutrition and flavor in the yellow suspension of a mutant strain ofFood chemistry: X · 2026Article
- Multidimensional Regulatory Network ofOncology research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aquaporins (AQPs) are membrane channels that facilitate the transport of water and small solutes. They are increasingly recognized for their role in cancer development, particularly colorectal cancer (CRC), where they regulate tumor microenvironment remodeling, cell migration, and proliferation. This study investigates metabolites derived from Lactiplantibacillus plantarum K25 (L. plantarum K25) as potential modulators of AQP8, a mitochondrial aquaporin implicated in CRC through its role in oxidative stress and metabolic regulation. Using GC-MS analysis, we identified (Z)-18-Octadec-9-enolide as a prominent bacterial metabolite with structural properties indicative of membrane interaction. Molecular docking revealed strong binding affinity (-6.2 kcal/mol) between this compound and the AQP8 pore region, with key interactions involving residues His182 and Asn194 near the channel’s selectivity filter. ADMET profiling indicated good membrane permeability (LogP 5.56) but also highlighted potential hepatotoxicity and hERG inhibition risks, necessitating further optimization for safety. Molecular dynamics simulations confirmed stable complex formation, with low RMSD fluctuations (< 2.0 Å) supporting binding stability. These in silico findings provide a computational hypothesis, that evolutionarily optimized microbiome-derived metabolites can modulate cancer-relevant aquaporins like AQP8, opening new avenues for CRC therapeutics. However, these computational insights require experimental validation in vitro and in vivo to assess biological activity, therapeutic efficacy, and safety. By leveraging host–microbe molecular crosstalk, this study proposes a novel microbiome-inspired strategy for anticancer drug discovery.
Indexed as
Identifiers
40742509What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.