Evidence map›Paper›PMID 40742481›Full record

ArticleDaru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences2025

The effect of Fe

Atefeh Mansuryar, Shima Bourang, Mehran Noruzpour, Hossein Ali Ebrahimi, Amin Amani, Sergio Granados-Principal, Jesús Calahorra

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Atefeh MansuryarDepartment of Pharmaceutics, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran.
Shima BourangDepartment of Agronomy and Plant Breeding, Faculty of Agriculture and Natural Resources, University of Mohaghegh Ardabili, Ardabil, Iran.ORCID http://orcid.org/0009-0008-6783-0072
Mehran NoruzpourDepartment of Agronomy and Plant Breeding, Faculty of Agriculture and Natural Resources, University of Mohaghegh Ardabili, Ardabil, Iran.
Hossein Ali EbrahimiDepartment of Pharmaceutics, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran. haliebrahimi@gmail.com.ORCID http://orcid.org/0000-0001-8025-8279
Amin AmaniDepartment of Agronomy and Plant Breeding, Faculty of Agriculture and Natural Resources, University of Mohaghegh Ardabili, Ardabil, Iran.
Sergio Granados-PrincipalDepartment of Biochemistry and Molecular Biology 2, School of Pharmacy, University of Granada, Granada, 18011, Spain.ORCID http://orcid.org/0000-0001-8773-9489
Jesús CalahorraGENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, Granada, 18016, Spain.

Funding

Ardabil University of Medical Sciences 1005688
6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe administration of 5-FU as the first chemotherapeutic agent for colorectal cancer, showed difficulties including short half-life and the development of resistance. One prominent approach to overcome these restrictions, is administration of 5-FU in conjunction with nanoparticles, particularly magnetic nanoparticles. In this study, Fe

methodsThe characteristics of these copolymers were investigated by

resultsThe results of NMR, FTIR and TGA analysis confirmed the successful synthesis of copolymers. A zeta potential of -18 mV and a spherical shape with an average size of 235 nm were characteristics of the synthesized PLA-HA/Fe

conclusionOne potential strategy for targeted drug delivery and HCT116 cell line control is to encapsulate 5-FU in magnetite nanoparticles (Fe HIGHLIGHTS: • Drug delivery efficiency is significantly improved while utilizing different ligands are functionalized on the surface of nanoparticles. • Encapsulation of Fe

Indexed as

Antimetabolites, AntineoplasticFluorouracilHyaluronic AcidMagnetite NanoparticlesCell SurvivalDrug CarriersDrug Delivery SystemsDrug LiberationGreen Chemistry TechnologyHCT116 CellsHumansPolyestersAntimetabolites, AntineoplasticDrug CarriersFluorouracilHyaluronic AcidMagnetite NanoparticlesPolyesterspoly(lactide)5-Fluorouracil (5-FU)Green synthesisHyaluronic acidMicellar nanoparticlesPolylactic acidTargeted drug delivery

Identifiers

PMID40742481
PMCPMC12314301

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.