ArticleJournal of molecular histology2025
Effects of aerial parts of Oliveria decumbens and Trachyspermum ammi aromatherapy on hematological parameters and tissue histopathology in female rats.
Article in Journal of molecular histology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAromatherapy using herbal essential oils has gained interest for its potential therapeutic effects, yet concerns persist regarding its systemic impact on blood parameters and organ histopathology. This study investigated the effects of inhaling Oliveria decumbens Vent. and Trachyspermum ammi L. essential oils on haematological indices and the histological structure of kidneys, lungs, and liver in female rats.
methodsIn this controlled laboratory study, twenty-five female Wistar rats (200–250 g) were randomly assigned to five groups (n = 5 each). Three groups were exposed to a 1:1 mixture of Oliveria decumbens and Trachyspermum ammi essential oils at concentrations of 10, 100, and 1000 ppm, respectively; a fourth group received 100 ppm of O. decumbens alone, while the control group was exposed to distilled water via nebulization. Essential oils were extracted through hydro-distillation and chemically profiled using gas chromatography–mass spectrometry (GC-MS). Inhalation exposure was conducted in a closed nebulization chamber. Following the intervention, hematological parameters (WBC, RBC, HGB, HCT) and inflammatory markers were assessed, and histopathological evaluations of lung, liver, and kidney tissues were performed to identify structural alterations associated with essential oil exposure.
resultsHaematological analysis like WBC, RBC, HGB, and HCT levels (The descriptive statistics for WBC and RBC showed mean WBC values ranging from 7.75 ± 1.31 to 10.73 ± 2.69 and RBC values ranging from 7.14 ± 0.19 to 7.81 ± 0.91 ) showed no significant differences between intervention and control groups (p > 0.05). Histopathological evaluations indicated a dose-dependent effect of essential oils on renal and hepatic tissues. Higher doses caused mild glomerular hypercellularity, congestion, and early tubular injury in kidneys, while hepatic tissue exhibited cytoplasmic swelling and inflammatory infiltration. Lung tissue showed moderate septal thickening and inflammatory changes at elevated doses. The control group showed minimal alterations compared to high-dose groups.
conclusionInhalation of Oliveria decumbens and Trachyspermum ammi essential oils was not associated with significant changes in haematological parameters, though mild to moderate, dose-dependent histopathological alterations were observed in kidney, liver, and lung tissues. These findings suggest potential localized tissue responses at higher exposure levels, warranting further studies to assess their clinical significance and long-term effects.
Indexed as
Identifiers
40742473What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.