ArticleNeurogenetics2025
Association of LRRK2 R1628P variant with Parkinson's disease in Kinh Vietnamese: a cross-sectional study.
Article in Neurogenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- LRRK2 p.G2385R and p.R1628P variants in a multi-ethnic Asian Parkinson's Cohort: epidemiology and clinical insights.NPJ Parkinson's disease · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
Parkinson's disease (PD) is a complex disorder with contributions by environmental and genetic factors. LRRK2 R1628P is a major genetic risk factor for developing PD in Asian populations. However, the effect of this variant in Kinh Vietnamese remains unclear. This study collected DNA samples of 832 subjects comprising 190 PD patients and 642 control cases, and the LRRK2 R1628P variant was genotyped using an allele-specific oligonucleotide PCR method. The prevalence of the GC genotype of LRRK2 R1628P was significantly higher in the PD group than in the control group, and the LRRK2 R1628P variant showed a significant association with PD with OR = 2.91 (95% CI = 1.50-5.62). LRRK2 R1628P was also found to be associated with PD in subpopulations for males, early-onset, and late-onset. These results emphasize the important genetic contribution of LRRK2 R1628P in the risk of developing PD in the Kinh Vietnamese population.
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