Evidence map›Paper›PMID 40742402›Full record

ArticleMolecular neurobiology2025

VEGF and the VEGF

Stefania Zimbone, Giuseppe Battiato, Stefano Conti Nibali, Irina Naletova, Noemi Anna Pesce, Vito De Pinto, Angela Messina, Andrea Magrì, Marianna Flora Tomasello, Giulia Grasso

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Stefania Zimbone *Institute of Crystallography, National Council of Research, Catania Unit, Catania, Italy.
Giuseppe Battiato *Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Stefano Conti NibaliDepartment of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Irina NaletovaInstitute of Crystallography, National Council of Research, Catania Unit, Catania, Italy.
Noemi Anna PesceInstitute of Crystallography, National Council of Research, Catania Unit, Catania, Italy.
Vito De PintoDepartment of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Angela MessinaDepartment of Biological, Geological and Environmental Sciences, University of Catania, Catania, Italy.
Andrea MagrìDepartment of Biological, Geological and Environmental Sciences, University of Catania, Catania, Italy. andrea.magri@unict.it.
Marianna Flora TomaselloInstitute of Crystallography, National Council of Research, Catania Unit, Catania, Italy. mariannaflora.tomasello@cnr.it.
Giulia GrassoInstitute of Crystallography, National Council of Research, Catania Unit, Catania, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular endothelial growth factor (VEGF) is best known for its role in angiogenesis, but emerging evidence suggests neurotrophic and neuroprotective functions most likely connected to energy homeostasis pathways. Using high-resolution respirometry, we investigated the role of VEGF in optimizing mitochondrial oxidative phosphorylation efficiency in neuronal-like cells. Our findings indicate that VEGF enhances coupling efficiency for ATP synthesis by reducing the uncoupled respiration, a process involved in mitochondrial dysfunction and neurodegeneration, as observed in Parkinson's disease (PD). To investigate the VEGF relevance in PD, we exposed differentiated SH-SY5Y cells to MPP

Indexed as

1-Methyl-4-phenylpyridiniumMitochondriaModels, BiologicalParkinson DiseasePeptide FragmentsVascular Endothelial Growth Factor ACell DeathCell Line, TumorDNA, MitochondrialHumansMembrane Potential, MitochondrialPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha1-Methyl-4-phenylpyridiniumDNA, MitochondrialPeptide FragmentsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaVascular Endothelial Growth Factor AMitochondriaMPP+NeurotrophicOxidative phosphorylation (OXPHOS)Parkinson’s disease (PD)PeptideVEGF

Identifiers

PMID40742402
PMCPMC12559092

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.