ArticleEpilepsia2025
Untangling the tangled relationship between cognitive and psychological comorbidities in epilepsy: Bidirectionality and mediation.
Article in Epilepsia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Untangling the tangled relationship between cognitive and psychological comorbidities in epilepsy: Bidirectionality and mediation.Epilepsia · 2025Article
- Editorial: Prevention of and early intervention for behavioral health disorders in people with epilepsy.Frontiers in neurology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveCognitive and psychological abnormalities are known to be frequently occurring complications of the epilepsies, but their patterns of co-occurrence, directions of effect, underlying mechanism(s), and causal pathways remain uncertain. The intent of this investigation was to advance understanding of these issues in patients with temporal lobe epilepsy (TLE).
methodsA total of 121 patients with TLE were administered a comprehensive neuropsychological battery, and symptoms of diverse psychological syndromes were assessed with a standardized psychological inventory. The cognitive and psychological data were reduced by factor analysis (FA) to broad- and narrowband indicators that were then examined by partial least squares structural equation modeling (PLS-SEM) to inform the presence, strength, direction, and mediators of cognitive-psychological relationships.
resultsFA identified overarching metrics of cognition (g) and psychopathology (p) as well as their correlation and underlying factors wherein g contained three indicators (language/memory, perceptual/nonverbal reasoning, information/processing speed) and p contained two indicators (externalizing, internalizing). PLS-SEM demonstrated direct, bidirectional associations between internalizing psychopathology and language/memory, indicating these factors express a strong interdependency. Mediation modeling showed an index of functional brain reserve served to explain this selective, shared influence, as well the relationship between the broader concepts of p and g, indicating origin in a common psychological/cognitive mechanism. SIGNIFICANCE: Neuropsychological and psychological comorbidities of TLE are represented by both broadband and narrowband indicators of clinical and theoretical relevance. These indicators exhibit multidimensionality, multimorbidity, and bidirectionality that point to a shared neurobiological core best expressed and explained by the mediating influence of brain functional reserve.
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Registered trials
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