Evidence map›Paper›PMID 40742260›Full record

ArticleThe New England journal of medicine2025

Resolution of Squamous-Cell Carcinoma by Restoring T-Cell Receptor Signaling.

Peiying Ye, Jenna R E Bergerson, Isaac Brownell, Gabriel J Starrett, Roshini S Abraham, Megan V Anderson, Triscia Martin, Derek MacMath, Hye Sun Kuehn, Jyothi Padiadpu and 8 more

Abstract readCase Reports
In one paragraph

Article in The New England journal of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Peiying YeLaboratory of Immunoregulation and Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD.
Jenna R E BergersonLaboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD.
Isaac BrownellDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD.
Gabriel J StarrettLaboratory of Cellular Oncology, National Cancer Institute (NCI), Bethesda, MD.
Roshini S AbrahamDepartment of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH.
Megan V AndersonLaboratory of Immunoregulation and Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD.
Triscia MartinClinical Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD.
Derek MacMathLaboratory of Immunoregulation and Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD.
Hye Sun KuehnDepartment of Laboratory Medicine, NIH Clinical Center, Bethesda, MD.
Jyothi PadiadpuLaboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, Bethesda, MD.
Siqi ZhaoImmune Regulation Unit, National Institute of Dental and Craniofacial Research, Bethesda, MD.
Sergio D RosenzweigDepartment of Laboratory Medicine, NIH Clinical Center, Bethesda, MD.
Roxane TussiwandImmune Regulation Unit, National Institute of Dental and Craniofacial Research, Bethesda, MD.
Warren J LeonardLaboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, Bethesda, MD.
Stefania PittalugaDepartment of Pathology, NCI, Bethesda, MD.
Mark RaffeldDepartment of Pathology, NCI, Bethesda, MD.
Danielle E ArnoldImmune Deficiency Cellular Therapy Program, NCI, NIH, Bethesda, MD.
Andrea LiscoLaboratory of Immunoregulation and Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD.ORCID 0000-0002-1475-356X

Funding

Immunopathogenesis of skin and mucosal Human Papillomavirus (HPV)-related diseases ZIAAI001310 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LISCO, ANDREA · 2020 to 2025
$2.7M
Intramural NIH HHS Z99 AI999999Intramural NIH HHS ZIA AI001310
6 · The paper itself

Abstract

Cutaneous squamous-cell carcinoma (SCC) is primarily caused by oncogenesis mediated by ultraviolet radiation, and β-human papillomavirus (β-HPV) is believed to be a mere facilitator that is dispensable for the maintenance of cutaneous SCC. Here, we describe a woman with benign and malignant HPV-related diseases that include a recurrent, unresectable, invasive cutaneous SCC with β-HPV19 genomic integration in the context of germline pathogenic mutations in

Indexed as

Carcinoma, Squamous CellHematopoietic Stem Cell TransplantationPapillomavirus InfectionsReceptors, Antigen, T-CellSkin NeoplasmsZAP-70 Protein-Tyrosine KinaseAdultCarcinogenesisFemaleGerm-Line MutationHumansPapillomaviridaeSignal TransductionSkinVirus IntegrationReceptors, Antigen, T-CellZAP70 protein, humanZAP-70 Protein-Tyrosine Kinase

Identifiers

PMID40742260
PMCPMC12370287

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.