Evidence map›Paper›PMID 40742148›Full record

ArticlemSystems2025

The diverse phenotypic and mutational landscape induced by fluoroquinolone treatment.

Sayed Golam Mohiuddin, Pouria Kavousi, Diego Figueroa, Sreyashi Ghosh, Mehmet A Orman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sayed Golam MohiuddinWilliam A. Brookshire Department of Chemical and Biomolecular Engineering, University of Houston, Houston, Texas, USA.ORCID 0000-0001-7613-6324
Pouria KavousiWilliam A. Brookshire Department of Chemical and Biomolecular Engineering, University of Houston, Houston, Texas, USA.
Diego FigueroaWilliam A. Brookshire Department of Chemical and Biomolecular Engineering, University of Houston, Houston, Texas, USA.
Sreyashi GhoshWilliam A. Brookshire Department of Chemical and Biomolecular Engineering, University of Houston, Houston, Texas, USA.
Mehmet A OrmanWilliam A. Brookshire Department of Chemical and Biomolecular Engineering, University of Houston, Houston, Texas, USA.ORCID 0000-0001-8499-9154

Funding

Characterizing a Self-Digesting-Mediated Reversible Drug Tolerance Mechanism in BacteriaR01AI143643 · NIAID · UNIVERSITY OF HOUSTON · PI ORMAN, MEHMET A. · 2020 to 2024
$1.9M
Investigating "viable but non-culturable" Cell and Persister Formation MechanismsK22AI125468 · NIAID · UNIVERSITY OF HOUSTON · PI ORMAN, MEHMET A. · 2018 to 2019
$270k
National Institute of Allergy and Infectious Diseases K22AI125468National Institute of Allergy and Infectious Diseases R01-AI143643NIAID NIH HHS K22 AI125468NIAID NIH HHS R01 AI143643University of Houston Start up grant
6 · The paper itself

Abstract

Antibiotic resistance remains a major public health challenge, yet the broader effects of antibiotic treatment on bacterial tolerance, resistance, and fitness are not fully understood. In this study, we investigated how

Indexed as

Anti-Bacterial AgentsDrug Resistance, BacterialEscherichia coliFluoroquinolonesMutationMicrobial Sensitivity TestsOfloxacinPhenotypeWhole Genome SequencingAnti-Bacterial AgentsFluoroquinolonesOfloxacinadaptive laboratory evolutionantibiotic resistanceantibiotic tolerancebacterial fitness factorsfluoroquinolonemutagenesisresistant mutants

Identifiers

PMID40742148
PMCPMC12363166

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.