Evidence map›Paper›PMID 40742008›Full record

ArticleAmerican journal of physiology. Cell physiology2025

Effect of IL-1β on pancreatic acinar cells mitochondrial TPP carrier-mediated uptake: inhibition mediated via the intracellular NF-κB signaling pathway.

Selvaraj Anthonymuthu, Subrata Sabui, Kalidas Ramamoorthy, Yusuf Ali Ahmed, Appakalai N Balamurugan, Hamid M Said

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Cell physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Selvaraj AnthonymuthuDepartment of Physiology and Biophysics, University of California, Irvine, California, United States.ORCID 0000-0001-7316-1436
Subrata SabuiDepartment of Physiology and Biophysics, University of California, Irvine, California, United States.
Kalidas RamamoorthyDepartment of Physiology and Biophysics, University of California, Irvine, California, United States.
Yusuf Ali AhmedDepartment of Physiology and Biophysics, University of California, Irvine, California, United States.
Appakalai N BalamuruganWendy Novak Diabetes Institute, Norton Children's Research Institute, Norton Healthcare, Division of Endocrinology, Department of Pediatrics, Pediatric Research Institute, University of Louisville, Louisville, Kentucky, United States.
Hamid M SaidDepartment of Physiology and Biophysics, University of California, Irvine, California, United States.ORCID 0000-0003-1016-8547

Funding

Physiology/Pathophysiology of Vitamin B1 Transport in Pancreatic Acinar CellsR01AA018071 · NIAAA · UNIVERSITY OF CALIFORNIA-IRVINE · PI SAID, HAMID M · 2009 to 2023
$6.3M
Vitamin B1 (thiamin) transport in Alzheimer’s Disease: Role of microRNAs in regulating level of expression of its transporters (SLC19A2 & SLC19A3) in human brain cells and effect of hypoxiaR01DK056061 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI SAID, HAMID M · 1999 to 2024
$5.0M
Mechanism/Regulation of Intestinal Thiamin UptakeR37DK056061 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI SAID, HAMID M · 2009 to 2018
$3.6M
BLRD VA I01 BX001142BLRD VA IK6 BX006189HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK56061HHS | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) AA018071HHS | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) AA-018071S1NIAAA NIH HHS R01 AA018071NIDDK NIH HHS R01 DK056061NIDDK NIH HHS R37 DK056061U.S. Department of Veterans Affairs (VA) I01BX001142U.S. Department of Veterans Affairs (VA) IK6BX006189
6 · The paper itself

Abstract

We investigated the effects of proinflammatory cytokines on carrier-mediated thiamin pyrophosphate (TPP) uptake by pancreatic acinar cells (PACs) mitochondria using mouse-derived pancreatic acinar 266-6 cells (PAC 266-6) and human primary PACs as models. First, we assessed the level of expression of the mitochondrial TPP transporter (MTPPT) mRNA in the pancreatic tissue of patients with chronic pancreatitis and found the level to be significantly lower than that in normal control subjects. We then examined the effects of exposing PACs to IL-1β, IL-6, and TNF-α on mitochondrial TPP uptake and observed significant inhibition by all these proinflammatory cytokines. Focusing on IL-1β (since it showed a more severe effect), we found this proinflammatory cytokine to also cause a significant inhibition in MTPPT protein and mRNA expression, as well as in the activity of the

Indexed as

Acinar CellsInterleukin-1betaMitochondriaNF-kappa BPancreasThiamine PyrophosphateAnimalsHumansMaleMiceMitochondrial ProteinsPancreas, ExocrinePancreatitis, ChronicSignal TransductionInterleukin-1betaMitochondrial ProteinsNF-kappa BThiamine Pyrophosphatemitochondrial thiamin pyrophosphate uptakeNF-κB signaling pathwaypancreatic acinar cellsproinflammatory cytokinesSLC25A19

Identifiers

PMID40742008
PMCPMC12396008

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.