Trial reportBJU international2025
Transcriptome profiling of prostatic tumours from ENACT trial patients with or without enzalutamide.
Trial report in BJU international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02799745 (A Randomized Study of Enzalutamide in Patients With Localized Prostate Cancer Undergoing Active Surveillance), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Study of Enzalutamide in Patients With Localized Prostate Cancer Undergoing Active Surveillance (ENACT)
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
objectivesTo evaluate the longitudinal transcriptomic changes that occurred over time in patients from the ENACT trial (ClinicalTrials.gov identifier: NCT02799745). ENACT evaluated patients with low- or intermediate-risk prostate cancer, comparing the efficacy and safety of enzalutamide plus active surveillance (AS) to AS alone. PATIENTS AND
methodsGene-expression profiling was conducted using the Decipher Genomic Resource for Intelligent Discovery (GRID) platform (Veracyte, Inc.) on 131 patient samples (enzalutamide plus AS: n = 57; AS alone: n = 74) collected at screening, Year 1, and Year 2. Pre-defined GRID signatures were analysed for associations with biological and clinical features, including immune activity, treatment sensitivity, metastatic risk, and molecular subtypes. Statistical analyses utilised Cox proportional hazards models and logistic/linear regression, while longitudinal changes were evaluated using linear mixed-effects models.
resultsAt Year 1, patients treated with enzalutamide plus AS showed significant transcriptomic changes, such as downregulation of androgen-receptor signalling and immune-suppressor signatures, alongside upregulation of immune-activated and basal-like markers. Many of these transcriptomic alterations, including immune-related changes, were transient and reverted to baseline levels at Year 2 after enzalutamide treatment cessation.
conclusionThis exploratory biomarker analysis highlights transcriptomic changes in patients undergoing AS and those treated with enzalutamide, providing insights into molecular disease progression on surveillance and the effects of transient exposure to enzalutamide. The observed immune modulation during enzalutamide treatment suggests opportunities to explore immunotherapy strategies.
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