ArticleArchives of endocrinology and metabolism2025
Increased levels of inflammatory markers and carotid intima-media thickness in asymptomatic patients with Sheehan syndrome without growth hormone replacement therapy.
Article in Archives of endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo evaluate whether inflammatory markers and carotid intima-media thickness are increased in patients with Sheehan syndrome.
methodsThis study included 37 patients diagnosed with Sheehan syndrome who met the eligibility criteria, along with 37 healthy controls matched for age, body mass index, and parity. All participants underwent a detailed clinical evaluation, along with measurement of biochemical and hormonal parameters, as well as inflammatory markers, specifically tumor necrosis factor alpha and interleukin-6. Both patients and controls were assessed for carotid intima-media thickness using a high-resolution color Doppler system.
resultsPatients with Sheehan syndrome had significantly higher mean levels of triglycerides, total cholesterol, and low-density lipoprotein cholesterol, along with lower levels of high-density lipoprotein cholesterol compared with controls. They also exhibited higher levels of tumor necrosis factor alpha (23.41 ± 10.97 pg/mL versus 20.05 ± 2.76 pg/mL; p = 0.041) and interleukin-6 (37.19 ± 5.38 pg/mL versus 32.08 ± 1.18 pg/mL; p = 0.004), as well as an increased mean carotid intima-media thickness value (0.71 ± 0.07 mm versus 0.59 ± 0.05 mm; p = 0.001).
conclusionPatients with Sheehan syndrome exhibited risk factors that may elevate their likelihood of developing atherosclerosis.
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