Evidence map›Paper›PMID 40741957›Full record

ArticleAntimicrobial agents and chemotherapy2025

Biological cost of aminoglycoside resistance Arm/Kam 16S rRNA methyltransferases from natural antibiotic producers and clinical pathogens.

Darija Vidučić, Sonja Obranić, Mihaela Matovina, Fedora Babić, Gordana Maravić-Vlahoviček

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Darija Vidučić *Department of Biochemistry and Molecular Biology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.
Sonja Obranić *Department of Biochemistry and Molecular Biology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.ORCID 0009-0001-9240-5982
Mihaela MatovinaDepartment of Biochemistry and Molecular Biology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.ORCID 0000-0001-7647-3339
Fedora BabićDepartment of Biochemistry and Molecular Biology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.ORCID 0000-0002-2290-6917
Gordana Maravić-VlahovičekDepartment of Biochemistry and Molecular Biology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.ORCID 0000-0002-0253-4028

Funding

European Commission 315997International Centre for Genetic Engineering and Biotechnology CRP/CRO08-02Ministry of Science and Technology, Croatia 006-0982913-1219
6 · The paper itself

Abstract

16S rRNA methyltransferases have emerged as critical elements of high-level aminoglycoside resistance in clinical pathogens. We investigated the fitness costs associated with the expression of six methyltransferases isolated from clinical strains (ArmA, RmtA, RmtB, RmtC, RmtD, and NpmA), and two methyltransferases from natural antibiotic producers (Sgm and KamB) in

Indexed as

AminoglycosidesAnti-Bacterial AgentsDrug Resistance, BacterialEscherichia coliEscherichia coli ProteinsMethyltransferasesRNA, Ribosomal, 16SMicrobial Sensitivity TestsAminoglycosidesAnti-Bacterial AgentsEscherichia coli ProteinsMethyltransferasesRNA, Ribosomal, 16S16S rRNA methyltransferasesaminoglycoside resistancebacterial fitnessfitness cost

Identifiers

PMID40741957
PMCPMC12406665

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.