ArticleCancer medicine2025
Efficacy and Safety of a 3-Weekly TS-1 Adjuvant Regimen in Advanced Gastric Cancer: A Pilot Study.
Article in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review of antiemetic therapy for low emetogenic chemotherapy: comparing 5-HTInternational journal of clinical oncology · 2026Pooled it
- Efficacy and Safety of a 3-Weekly TS-1 Adjuvant Regimen in Advanced Gastric Cancer: A Pilot Study.Cancer medicine · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundTS-1 at 80 mg/m
methodsWe analyzed 93 patients with stage II/III AGC who started 3-weekly adjuvant TS-1 therapy between Feb 2017 and May 2022 post-gastrectomy with D2 lymphadenectomy. The 3-weekly regimen was TS-1 at 80 mg/m
resultsAmong 93 patients, 12 (13%) had disease recurrence during follow-up (median 24.6 months, range 4.2%-63.3%). Seven (9.5%) with stage II (n = 73) and five (25%) with stage III (n = 20) experienced recurrence. Kaplan-Meier analysis estimated that Recurrence-Free Survival (RFS) rates at 1, 3, and 5 years were 92.0% (95% CI; 86.5%-97.9%), 84.7% (95% CI; 76.4%-93.9%), and 78.6% (95% CI; 65.8%-94.0%), respectively. Eighty patients (86%) completed the treatment; 25 (26.9%) needed dose reduction. Adverse events, mostly grade 1 or 2 diarrhea (28%) and nausea (20%), were manageable.
conclusionOur study revealed that the 3-weekly TS-1 regimen as adjuvant therapy exhibited good efficacy and manageable toxicity. This regimen as an adjuvant therapy for AGC should be evaluated in future studies.
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