ArticleJournal of cosmetic dermatology2025
Correlation Between External and Internal Skin Aging Markers by Skin Depth.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Senotherapeutic Potential of Araliadiol in Senescent Human Dermal Fibroblasts: An In Vitro Study Using Three Senescence Models.Pharmaceutics · 2025Article
- Correlation Between External and Internal Skin Aging Markers by Skin Depth.Journal of cosmetic dermatology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe skin is a complex, multilayered organ with diverse structures. Skin aging is a gradual process that begins internally, initially invisible to the eye, and eventually manifests as visible signs such as wrinkles and sagging.
aimsTo investigate the effects of characteristic changes in different skin layers on visible signs of aging, such as wrinkles and sagging.
methodsA total of 65 Korean women aged 20-65 years participated in this study. Skin characteristics were categorized into visible external and invisible internal markers. External markers included wrinkles and sagging, whereas internal markers included hydration, elasticity, density, thickness, and dermal-subcutaneous interface length. Internal markers were measured in greater detail at various skin depths. Spearman's correlation was used to analyze relationships between all skin parameters, including age.
resultsVisible signs of aging such as wrinkles and sagging increased with age. The elasticity indicators in each skin layer tended to decrease. No correlation was observed between moisture levels and age. The results of the correlation analysis between external and internal markers varied according to skin layer. Negative correlations were observed between skin sagging and epidermal moisture content in the epidermis and between wrinkles and elasticity indicators (Ue and Ur) in the deeper dermis layer.
conclusionsExternal markers are most strongly correlated with chronological age. However, visible aging is significantly influenced by changes in internal markers across different skin layers. Sagging is affected by moisture content within the epidermal layer, and wrinkles are affected by elasticity within the dermal layer.
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