Evidence map›Paper›PMID 40741648›Full record

ArticleMolecular pharmaceutics2025

Pharmacokinetics and Biodistribution of Polymeric Nanoparticles Loaded with a Small Molecule Drug in Mice with Alcoholic Liver Disease.

Jingyi Ma, Qiaoyu Pan, Sohan Mahto, Raghu Ramanathan, Altab Shaikh, Virender Kumar, Chalet Tan, Ram I Mahato

Abstract read
In one paragraph

Article in Molecular pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Therapeutics for Alcohol-Associated Liver Disease.Annual review of pharmacology and toxicology · 2026
    Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jingyi MaDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
Qiaoyu PanDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
Sohan MahtoDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
Raghu RamanathanDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
Altab ShaikhDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
Virender KumarDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
Chalet TanDepartment of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
Ram I MahatoDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.ORCID 0000-0003-3588-0434

Funding

Development and Preclinical Evaluation of Nanoformulations in Liver Fibrotic MiceR01DK135817 · NIDDK · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Ram I. Mahato, NATALIA ALEKSANDR OSNA · 2023 to 2026
$1.6M
Targeted Delivery of TFOs for Treatment of Liver FibrosisR01EB003922 · NIBIB · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI MAHATO, RAM I. · 2007 to 2010
$904k
NIBIB NIH HHS R01 EB003922NIDDK NIH HHS R01 DK135817
6 · The paper itself

Abstract

We recently demonstrated the therapeutic efficacy of a novel phosphodiesterase 4B (PDE4B) inhibitor, KVA-D88, loaded in mPEG-

Indexed as

Liver Diseases, AlcoholicNanoparticle Drug Delivery SystemPhosphodiesterase 4 InhibitorsAnimalsDrug Evaluation, PreclinicalFibrosisLiverMaleMiceMice, Inbred C57BLNanoparticle Drug Delivery SystemPhosphodiesterase 4 Inhibitorsalcohol-associated liver diseasebiodistributionnanoparticlespharmacokineticsphosphodiesterase 4 inhibitor

Identifiers

PMID40741648
PMCPMC13160285

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.