ArticleCytotechnology2025
Vanillin restrains proliferation of triple negative breast cancer cells by inducing ferroptosis via mediating the KLF2/GPX4 axis.
Article in Cytotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with poor prognosis. Treatment options of TNBC are limited, which is prone to recurrence and metastasis, posing a serious threat to patients' health. Recent studies revealed the important role of ferroptosis in TNBC. Vanillin is a phenolic aldehyde extracted from natural vanilla pods with multiple pharmacological activities, including anti-tumor properties. The present study aimed to explore the potential of vanillin in treating TNBC from the perspective of inducing ferroptosis. BT549 and MDA-MB-231 cells were incubated with 8 and 16 μM Vanillin for 24 h. Significantly decreased colony number, enhanced ROS, MDA, and GSSG levels, and reduced GSH levels and SOD activities in BT549 and MDA-MB-231 cells were triggered by 8 and 16 μM Vanillin, accompanied by increased Fe
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