ReviewCureus2025
The Effect of Drug Selection on Pediatric Rapid Sequence Induction Success: A Systematic Review and Meta-Analysis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this systematic review is to evaluate the effect of drug selection on endotracheal intubation conditions, hemodynamic response, and time course of neuromuscular blockade in children undergoing rapid sequence intubation (RSI). We systematically searched databases with no time restrictions for studies related to pediatric RSI and induction agents, as well as neuromuscular blockers. The inclusion criteria consisted of randomized controlled trials (RCTs) that studied pediatric patients who had undergone RSI. Studies involving any number of adult patients were excluded, as were studies that included opioids as induction agents. Seven RCTs (520 participants) were included. Five of the studies reported primary outcomes related to endotracheal intubation conditions, with four of these using identical methods for recording jaw relaxation, vocal cord positioning, and diaphragmatic response. Subgroup meta-analysis of these four studies reported an odds ratio of 3.38 (95% confidence interval, 1.45-7.90) for excellent intubating conditions, favoring rocuronium over other neuromuscular blockers. This meant that patients given rocuronium were 3.38 times more likely to have excellent intubating conditions compared to other neuromuscular blockers, and that this result was not due to chance. Suxamethonium consistently had faster onset and recovery times. Our systematic review demonstrated that rocuronium provides superior intubating conditions, allowing for improved first-pass success rates in pediatric RSI. Future studies should evaluate the effect of different induction agents on endotracheal intubation conditions and whether the RSI procedure itself improves mortality compared to other intubation methods.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.