Evidence map›Paper›PMID 40741574›Full record

ReviewCureus2025

Efficacy and Safety of Centchroman in the Treatment of Breast Fibroadenoma: A Systematic Review and Meta-Analysis.

Keshav Kumar, Kumari Pallavi, Kumar Martand, Lalit Mohan, Sukalyan Saha Roy, Prem Prakash, Vikas Maharshi

Abstract readReview
In one paragraph

Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Keshav KumarDepartment of Pharmacology and Therapeutics, Indira Gandhi Institute of Medical Sciences, Patna, IND.
Kumari PallaviDepartment of Pharmacology and Therapeutics, Indira Gandhi Institute of Medical Sciences, Patna, IND.
Kumar MartandDepartment of Anatomy, Employees State Insurance-Post Graduate Institute of Medical Sciences and Research (ESI-PGIMSR) Employees State Insurance Corporation (ESIC) Medical College, Joka, Kolkata, IND.
Lalit MohanDepartment of Pharmacology and Therapeutics, Indira Gandhi Institute of Medical Sciences, Patna, IND.
Sukalyan Saha RoyDepartment of Pharmacology and Therapeutics, Indira Gandhi Institute of Medical Sciences, Patna, IND.
Prem PrakashDepartment of Surgery, Indira Gandhi Institute of Medical Sciences, Patna, IND.
Vikas MaharshiDepartment of Pharmacology, All India Institute of Medical Sciences, Patna, IND.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast fibroadenoma is a benign disease in women of reproductive age group which usually presents as painless, solitary, or multiple lumps located in the same or both breasts. Management of breast fibroadenoma ranges from watchful observation for self-regression to surgical interventions. Many studies have evaluated centchroman for its efficacy and safety in the treatment of breast fibroadenoma, but their findings were conflicting. We, therefore, aimed to conduct this systematic review and meta-analysis to resolve the conflict. The primary objective was to assess the efficacy whereas the secondary objective was to assess the safety of centchroman compared with no intervention-only watchful waiting, placebo or any active control in patients with breast fibroadenoma.  The protocol for this systematic review and meta-analysis was designed

Indexed as

breast fibroadenomacentchromanmeta-analysisormeloxifenesystematic review

Identifiers

PMID40741574
PMCPMC12310075

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.