Enhanced transdermal delivery of lidocaine cream via ultrasound and microneedle rollers.

Jiaxiao Sun, Yang Yang, Juanjuan Zheng, Hao Liang, Feng Yan, Wensheng Zhang, Wenqin Xie

Abstract read

In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiaxiao Sun *Department of Anesthesiology, Quanzhou First Hospital, Fujian Medical University, Quanzhou, Fujian, China.

Yang Yang *Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Juanjuan ZhengDepartment of Medical Record, Quanzhou First Hospital, Fujian Medical University, Quanzhou, Fujian, China.

Hao LiangSchool of Automation Engineering, University of Electronic Science and Technology, Chengdu, Sichuan, China.

Feng YanDepartment of Ultrasound and Clinical Ultrasound Imaging Drug Research Lab, West China Hospital, Chengdu, Sichuan, China.

Wensheng ZhangDepartment of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Wenqin XieDepartment of Anesthesiology, Quanzhou First Hospital, Fujian Medical University, Quanzhou, Fujian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The aim of this study is to determine the most effective physical parameters for optimizing the transdermal delivery of lidocaine cream. Methods: Preliminary experiments were conducted to optimize ultrasound settings while ensuring safety, guided by visual and histopathological evaluations following observations of skin burns in rats. Results: Twelve non-invasive parameter configurations involving ultrasound and microneedle rollers were identified. The combination of ultrasound and microneedle rollers yielded superior results while the ultrasound-only groups demonstrated improved diffusion compared to the control. Notably, ultrasound applied at 260 kHz with a 90% duty cycle, in conjunction with microneedle rollers, achieved the highest diffusion rates, with Conclusion: Microneedle rollers demonstrate superior clinical efficacy over ultrasound, enabling rapid lidocaine delivery (15-min onset

Indexed as

anesthesiologylidocaine creammicroneedle rollertransdermalultrasound

Identifiers

PMID40741537

DOI10.3389/fbioe.2025.1612145

PMCPMC12307353

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.