ArticleJournal of hand surgery global online2025
Associations of Demographic, Lifestyle, and Clinical Factors With the Presence of Dupuytren Disease: Results from the Lifelines Cohort Study.
Article in Journal of hand surgery global online, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Many risk factors have been associated with Dupuytren disease (DD), but their contribution is still unclear. Therefore, we aimed to investigate the associations of a wide range of risk factors with the presence of DD in Lifelines, an ongoing prospective population-based cohort study with >165,000 participants initiated in 2006. Methods: The presence of DD was determined through questionnaires by self-reported doctor's diagnosis. The association between demographic, lifestyle, and clinical factors and DD was analyzed using logistic regression adjusted for age, age Results: Overall, 1,320 (2.1%) Lifelines participants reported to have DD. Age, age Conclusions: Older age and male sex were the predominant factors increasing DD risk, but anthropometric measures of adiposity, (osteo)arthritis, anti-inflammatory and antirheumatic drugs, high-density lipoprotein levels, triglyceride levels, alcohol use, diabetes and diabetes medication also contributed significantly to the final risk model for DD. In particular, the joint related factors are of interest because previous evidence for these risk factors was inconclusive. Clinical relevance: Our risk model presents an opportunity for prevention of DD. Future studies should elucidate the role of rheumatoid arthritis in DD. Risk models may possibly enable the creation of accurate individual risk profiles of DD leading to optimization of care.
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