Evidence map›Paper›PMID 40741481›Full record

ArticlebioRxiv : the preprint server for biology2024

NuMA mechanically reinforces the spindle independently of its partner dynein.

Nathan H Cho, Merve Aslan, Ahmet Yildiz, Sophie Dumont

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Nathan H ChoDepartment of Bioengineering & Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-0110-1343
Merve AslanBiophysics Graduate Group, University of California, Berkeley, Berkeley, CA, USA.
Ahmet YildizBiophysics Graduate Group, University of California, Berkeley, Berkeley, CA, USA.
Sophie DumontDepartment of Bioengineering & Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.

Funding

The Mechanism and Regulation of the Dynein Transport MachineryR35GM136414 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Ahmet Yildiz · 2020 to 2026
$5.1M
Assembly and function of cytoskeletal systems in eukaryotic and prokaryoticcellsR35GM118119 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MULLINS, R DYCHE · 2016 to 2025
$4.8M
Microscopy system upgradeR35GM136420 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Sophie Dumont · 2020 to 2026
$4.6M
Defining the mechanisms by which NuMA drives spindle mechanical robustnessF31CA275394 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHO, NATHAN · 2023 to 2025
$89k
NCI NIH HHS F31 CA275394NIGMS NIH HHS R35 GM118119NIGMS NIH HHS R35 GM136414NIGMS NIH HHS R35 GM136420
6 · The paper itself

Abstract

Both motor and non-motor proteins organize microtubules to build the spindle and maintain it against opposing forces. NuMA, a long microtubule binding protein, is essential to spindle structure and function. NuMA recruits the motor dynein to spindle microtubule minus-ends to actively cluster them, but whether NuMA performs other spindle roles remains unknown. Here, we show that NuMA acts independently of dynein to passively reinforce the mammalian spindle. NuMA that cannot bind dynein is sufficient to protect spindle poles against fracture under external force. In contrast, NuMA with a shorter coiled-coil or disrupted self-interactions cannot protect spindle poles, and NuMA turnover differences cannot explain mechanical differences.

Identifiers

PMID40741481
PMCPMC12309564

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.