ArticleArchives of medical science : AMS2025
MicroRNA-939 induces apoptosis in human liver cancer cells by targeting CRKL expression.
Article in Archives of medical science : AMS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Over the years, microRNAs (miRs) have been shown to exhibit therapeutic implications in the treatment of cancer. Consistently, this study was designed to examine the expression profile and to decipher the therapeutic implications of miR-939 in human liver cancer. Material and methods: Expression profiling was performed by qRT-PCR and the proliferation rate of liver cancer cells was monitored by Cell Counting Kit 8 (CCK8) and clonogenic assays. 4',6-diamidino-2-phenylindole (DAPI) staining and annexin V-FITC assays were used to determine the induction of apoptosis. Ultrastructural analysis was performed by transmission electron microscopy (TEM). Western blotting was used to determine protein expression. Results: miR-939 was found to be significantly ( Conclusions: The present study established the role of the miR-939/CRKL molecular axis in regulation of liver cancer proliferation, and it may also prove an essential therapeutic target for its management.
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