Evidence map›Paper›PMID 40741240›Full record

ArticleArchives of medical science : AMS2025

Exploring the mediating role of the plasma lipidome in the pathway from the gut microbiota to dementia: a Mendelian randomization study.

Binghan Li, Xu Sun, Xiao Luo, Yuting Kan, Weisen Wang, Tianren Wang, Cheng Wu, Yongbo Hu, Xiaoying Bi

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In one paragraph

Article in Archives of medical science : AMS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Binghan LiDepartment of Neurology, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Xu SunDepartment of Neurology, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Xiao LuoDepartment of Military Health Statistics, Naval Medical University, Shanghai, China.
Yuting KanDepartment of Neurology, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Weisen WangDepartment of Neurology, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Tianren WangDepartment of Neurology, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Cheng WuDepartment of Military Health Statistics, Naval Medical University, Shanghai, China.
Yongbo HuDepartment of Neurology, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Xiaoying BiDepartment of Neurology, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Previous studies have indicated a potential association between the gut microbiota (GM) and dementia; however, the exact cause-and-effect relationships between GM, various types of dementia, and the potential influence of the plasma lipidome as intermediaries are still unclear. Material and methods: We used genome-wide association study (GWAS) data to identify GM taxa, plasma lipid species (lipidome), and five types of dementia: Alzheimer's disease (AD), dementia with Lewy bodies (DLB), Parkinson's disease dementia (PDD), frontotemporal dementia (FTD) and vascular dementia (VD). We used Mendelian randomization (MR) to investigate the possible causal connections among the GM, plasma lipidome, and dementias. The inverse variance weighting (IVW) method served as the primary statistical approach. We investigated the role of plasma lipidome as a potential mediating factor in this relationship. Results: A total of 41 positive and 39 negative causal relationships between genetic susceptibility in the GM taxa or bacterial pathways and dementia, as well as 14 negative causal relationships between the plasma lipidome and dementias, were identified. Additionally, only 1 potential mediation pathway was identified as having a significant mediating effect. Conclusions: Our results suggest a link between the GM and the plasma lipidome with five distinct types of dementia, indicating that the phosphatidylcholine (O-16:1_18:2) level could play a role in the pathway from the species

Indexed as

dementiagut microbiotaMendelian randomizationplasma lipidome

Identifiers

PMID40741240
PMCPMC12305551

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