Evidence map›Paper›PMID 40741201›Full record

ArticleWorld journal of clinical oncology2025

Proton pump inhibitors and mortality in patients with cancer: Unraveling the complex link.

Ibtehaj Tariq, Qurat Ul Ain Iftikhar, Abdulqadir J Nashwan

Abstract readLetter
In one paragraph

Article in World journal of clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ibtehaj TariqDepartment of Hepatobiliary and Liver and Kidney Transplant, Bahria International Hospital Orchard, Lahore 54780, Punjab, Pakistan.
Qurat Ul Ain IftikharDepartment of Medicine, Islamic International Medical College, Rawalpindi 44000, Pakistan.
Abdulqadir J NashwanDepartment of Nursing, Hamad Medical Corporation, Doha 3050, Qatar. anashwan@hamad.qa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proton pump inhibitors (PPIs) are widely utilized in oncology to treat gastroesophageal reflux disease, peptic ulcer disease, and chemotherapy-induced mucosal injury. Emerging evidence has suggested that prolonged use of PPIs is associated with increased mortality in patients with cancer. The findings of Krishnan

Indexed as

Acid suppression therapyCancer mortalityClinical pharmacologyConfounding by indicationGastrointestinal complicationsObservational studyOncology treatmentPolypharmacyProton pump inhibitorsReverse causality

Identifiers

PMID40741201
PMCPMC12304971

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.