Evidence map›Paper›PMID 40741088›Full record

ArticleMaterials and interfaces2024

A Novel Bi-Directional and Bi-Temporal Delivery System for Enhancing Intrasynovial Tendon Repair.

Yidan Chen, Seth Kinoshita, Emily Yan, Min Hao, Hua Shen, Richard Gelberman, Stavros Thomopoulos, Younan Xia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials and interfaces, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yidan ChenSchool of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Seth KinoshitaSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Emily YanThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.
Min HaoThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.
Hua ShenDepartment of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Richard GelbermanDepartment of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Stavros ThomopoulosDepartment of Orthopedic Surgery, Department of Biomedical Engineering, Columbia University, New York, NY 10032, USA.
Younan XiaSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA.

Funding

Enhanced Tendon Healing Through Growth Factor and Cell TherapiesR01AR062947 · NIAMS · WASHINGTON UNIVERSITY · PI GELBERMAN, RICHARD H, THOMOPOULOS, STAVROS · 2012 to 2022
$5.5M
Biomimetic approaches for enthesis tissue engineeringR01AR080924 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Stavros Thomopoulos, YOUNAN XIA · 2023 to 2026
$1.9M
NIAMS NIH HHS R01 AR062947NIAMS NIH HHS R01 AR080924
6 · The paper itself

Abstract

Flexor tendon injuries are common and often require surgical repair and prolonged rehabilitation. Successful clinical outcomes depend on the concurrent suppression of adhesions (caused by inflammation) at the tendon surface and promotion of matrix synthesis inside the tendon. Herein, we report a bi-directional and bi-temporal drug delivery system designed to target both the initial inflammatory phase and the subsequent proliferative and remodeling phases of healing to improve outcomes after flexor tendon repair. The system features a multi-layered design with anti-adhesion and pro-matrix factors encapsulated in separate layers of hyaluronate films crosslinked to different degrees to control their direction and rate of release. After validating drug delivery under controlled release, cell culture experiments involving tendon fibroblasts and a Transwell system are conducted to demonstrate the system's efficacy in modulating local cellular responses. The promising results from this study lay the groundwork for moving this system toward in vivo testing and clinical translation.

Indexed as

controlled releasedrug deliveryflexor tendon repairsodium hyaluronateTranswell cell culture

Identifiers

PMID40741088
PMCPMC12309398

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.