ArticleClinical and experimental vaccine research2025
Assessment of naturally acquired IgG antibodies to pneumococcal vaccine serotypes in healthy and type 2 diabetic adults in India.
Article in Clinical and experimental vaccine research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Materials and Methods: This study aimed to measure baseline immunoglobulin G (IgG) antibody levels against 23 vaccine serotypes in 56 type 2 diabetic and 56 healthy Indian adults using the World Health Organization-enzyme-linked immunosorbent assay protocol. Results: Protective IgG levels (≥1.3 µg/mL) were observed for 78% of serotypes (18/23) in healthy adults but only 35% (8/23) in diabetics. Significant differences were noted in 13 of 23 serotypes (56.2%), including 1, 6B, 7F (p=0.008), 8 (p=0.01), 9V, 11A (p=0.009), 12F, 17F, 18C (p=0.002), 19A (p=0.0006), 19F (p=0.004), 22F (p=0.0003), and 33F (p=0.04). Serotype 14 showed the highest IgG levels, while serotype 3 had the lowest. Seroprevalence ranged from 17.8% to 98.21% in non-diabetics and 10.7% to 96.4% in diabetics. Conclusion: The findings highlight differences in baseline immunity and provide insights into pneumococcal immunogenicity in Indian adults with and without diabetes.
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