ArticleRSC medicinal chemistry2025
Microwave-assisted synthesis of tubulin assembly inhibitors as anticancer agents by aryl ring reversal and conjunctive approach.
Domiziana Masci, Michela Puxeddu, Claudia Colla, Antonio Coluccia, Martina Santelli, Pietro Sciò, Elena Mariotto, Giampietro Viola, Ernest Hamel, Rosa Lerose and 3 more
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In one paragraphArticle in RSC medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
13 authors.
Domiziana MasciDepartment of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Catholic University of the Sacred Heart Largo Francesco Vito 1 00168 Rome Italy.ORCID https://orcid.org/0000-0002-5615-5111 Michela PuxedduLaboratory affiliated with the Institute Pasteur Italy - Cenci Bolognetti Foundation, Department of Drug Chemistry and Technologies, Sapienza University of Rome Piazzale Aldo Moro 5 00185 Rome Italy romano.silvestri@uniroma1.it.
Claudia CollaLaboratory affiliated with the Institute Pasteur Italy - Cenci Bolognetti Foundation, Department of Drug Chemistry and Technologies, Sapienza University of Rome Piazzale Aldo Moro 5 00185 Rome Italy romano.silvestri@uniroma1.it.
Antonio ColucciaLaboratory affiliated with the Institute Pasteur Italy - Cenci Bolognetti Foundation, Department of Drug Chemistry and Technologies, Sapienza University of Rome Piazzale Aldo Moro 5 00185 Rome Italy romano.silvestri@uniroma1.it.
Martina SantelliDepartment of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Catholic University of the Sacred Heart Largo Francesco Vito 1 00168 Rome Italy.
Pietro SciòLaboratory affiliated with the Institute Pasteur Italy - Cenci Bolognetti Foundation, Department of Drug Chemistry and Technologies, Sapienza University of Rome Piazzale Aldo Moro 5 00185 Rome Italy romano.silvestri@uniroma1.it.
Elena MariottoDepartment of Woman's and Child's Health, University of Padua, Hemato-oncology Lab Via Giustiniani 3 35128 Padua Italy.
Ernest HamelMolecular Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, Frederick National Laboratory for Cancer Research, National Cancer Institute, National Institutes of Health Frederick Maryland 21702 USA.ORCID https://orcid.org/0000-0003-3648-103X Rosa LeroseHospital Pharmacy, Centro di Riferimento Oncologico della Basilicata (IRCCS-CROB) 85028 Rionero in Vulture Italy.
Carmela MazzoccoliHospital Pharmacy, Centro di Riferimento Oncologico della Basilicata (IRCCS-CROB) 85028 Rionero in Vulture Italy.
Romano SilvestriLaboratory affiliated with the Institute Pasteur Italy - Cenci Bolognetti Foundation, Department of Drug Chemistry and Technologies, Sapienza University of Rome Piazzale Aldo Moro 5 00185 Rome Italy romano.silvestri@uniroma1.it.ORCID https://orcid.org/0000-0003-2489-0178 Giuseppe La ReginaLaboratory affiliated with the Institute Pasteur Italy - Cenci Bolognetti Foundation, Department of Drug Chemistry and Technologies, Sapienza University of Rome Piazzale Aldo Moro 5 00185 Rome Italy romano.silvestri@uniroma1.it.ORCID https://orcid.org/0000-0003-3252-1161 Funding
CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001E
6 · The paper itselfAbstract
Microwave-assisted synthesis of new pyrrole and indole derivatives as tubulin assembly inhibitors was performed with remarkably improved yields and short reaction times. In designing the new inhibitors, aryl ring reversal and conjunctive approach notions were applied. (4-(4-Methoxyphenyl)-1-(pyridin-2-yl)-1
Identifiers
PMID40741052
PMCPMC12306498
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