Evidence map›Paper›PMID 40741045›Full record

ArticleFrontiers in aging neuroscience2025

Lower hippocampal volumes at baseline are associated with higher volume loss in healthy elderly.

Vivian Schultz, Benita Schmitz-Koep, Aurore Menegaux, Melissa Thalhammer, Severin Schramm, Su Hwan Kim, Claus Zimmer, Christian Sorg, Panteleimon Giannakopoulos, Marie-Louise Montandon and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Vivian SchultzDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine and Health, TUM Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Benita Schmitz-KoepDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine and Health, TUM Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Aurore MenegauxDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine and Health, TUM Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Melissa ThalhammerDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine and Health, TUM Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Severin SchrammDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine and Health, TUM Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Su Hwan KimDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine and Health, TUM Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Claus ZimmerDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine and Health, TUM Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Christian SorgDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine and Health, TUM Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Panteleimon GiannakopoulosDepartment of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Marie-Louise MontandonDepartment of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
François R HerrmannDepartment of Surgical Sciences, Neuroradiology, Uppsala University, Uppsala, Sweden.
Cristelle RodriguezDepartment of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Sven HallerCIMC - Centre d'Imagerie Médicale de Cornavin, Geneva, Switzerland.
Dennis M HedderichDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine and Health, TUM Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Hippocampal volume loss occurs physiologically with age, but an accelerated rate of volume loss is linked to neurodegenerative diseases. While evidence suggests that cross-sectional study designs tend to underestimate hippocampal atrophy rates compared to longitudinal approaches, few studies have directly examined the relationship between these two methods in the context of brain aging. This study aims to investigate the association between baseline hippocampal z-scores and hippocampal volume loss over time in a cohort of healthy older adults. Methods: 182 healthy elderly subjects (mean age: 73.4 ± 3.5 years) who underwent structural Magnetic resonance imaging (MRI) at two timepoints (mean time between the scans 4.8 ± 1.0 years) were included. A subset of participants ( Results: Hippocampal volumes decreased from baseline to follow-up [mean APC (SD): right -1.34% (0.94), left: -1.79% (1.00)]. Small, but statistically significant positive correlations were found between baseline hippocampal z-scores and APC of hippocampal volumes over time, indicating that the lower the volume at baseline, the greater the atrophy rate to timepoint two (right hippocampus: Conclusion: Lower baseline hippocampal z-scores are associated with a greater rate of hippocampal atrophy to the follow-up examination. If validated in larger cohorts, these findings could help establish cut-off values for pathological atrophy in cross-sectional studies.

Indexed as

agingatrophybrainhippocampusMRIneurodegeneration

Identifiers

PMID40741045
PMCPMC12307302

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.