ArticleWorld journal of cardiology2025
Impact of glucagon-like peptide-1 receptor agonists on the incidence of atrial fibrillation.
Article in World journal of cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Research on epicardial adipose tissue as a metabolic therapeutic target in AF: focus on GLP-1 receptor agonists.Frontiers in cardiovascular medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAtrial fibrillation (AF) stands as the most prevalent type of arrhythmia, affecting approximately 60 million individuals world-wide. Although antiarrhythmic drugs (AADs) remain the gold standard for AF treatment, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are arising as potential therapeutic alternatives.
aimTo evaluate the impact of GLP-1 RAs on the incidence of AF.
methodsInclusion criteria included systematic reviews (SRs) that based their analyses on clinical trials, observational studies, controlled trials and network meta-analyses. A total of 8 SRs were selected for data extraction, focusing on semaglutide, liraglutide and dulaglutide. Additionally, the effects of GLP-1 RAs on AF incidence were compared with those of sodium-glucose co-transporter 2 (SGLT2) inhibitors.
resultsFindings indicate that semaglutide, evaluated in the largest patient cohort across the 8 SRs, consistently reduced AF incidence. However, dulaglutide and liraglutide exhibited inconsistent effects. Notably, as opposed to variable outcomes associated with GLP-1 RAs, SGLT2 inhibitors a class of antidiabetic agents with weight-reducing properties exhibit significant cardiovascular benefits, including reductions in both AF and atrial flutter.
conclusionGLP-1 RAs emerge as a promising and potential alternative for AADs in reduction of incidence of AF. However, further research is required to fully determine their therapeutic potential and long-term cardiovascular effects.
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