Evidence map›Paper›PMID 40740970›Full record

ReviewJournal of inflammation research2025

Exploring the Importance of ZBP1 in Sepsis: A Mini Review on It's Mechanisms and Progress.

Jie Liu, Jian Feng, Jian Hu, Juan Chen, Fu-Xiang Li, Ning Lin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jie Liu *Department of Clinical Nutrition, The General Hospital of Western Theater Command, Chengdu, Sichuan, 610083, People's Republic of China.ORCID 0009-0000-3430-3577
Jian Feng *Department of Critical Care Medicine, The General Hospital of Western Theater Command, Chengdu, Sichuan, 610083, People's Republic of China.
Jian HuDepartment of Critical Care Medicine, The General Hospital of Western Theater Command, Chengdu, Sichuan, 610083, People's Republic of China.
Juan ChenDepartment of Critical Care Medicine, The General Hospital of Western Theater Command, Chengdu, Sichuan, 610083, People's Republic of China.
Fu-Xiang LiCollege of Medicine Southwest Jiaotong University, Chengdu, Sichuan, 610031, People's Republic of China.
Ning LinDepartment of Clinical Nutrition, The General Hospital of Western Theater Command, Chengdu, Sichuan, 610083, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis is defined as a severe systemic inflammation, often triggered by an infection, resulting in organ dysfunction and mortality. In recent years, ZBP1 (Z-DNA binding protein 1) has garnered significant attention as a critical immune regulatory factor in the pathogenesis of sepsis. This article aims to comprehensively explore the mechanisms by which ZBP1 operates in sepsis and summarize the relevant research progress. This study will seek to highlight the potential of ZBP1 as a therapeutic target and biomarker in the context of sepsis through an in-depth analysis of its functions in cellular signaling, inflammatory response, and immune response. This review seeks to provide new insights for the clinical management of sepsis.

Indexed as

immune regulationinflammatory responseresearch progresssepsisZBP1

Identifiers

PMID40740970
PMCPMC12307968

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.