Evidence map›Paper›PMID 40740928›Full record

ReviewWorld journal of gastrointestinal surgery2025

Genetically engineered mouse models in gastric precancerous lesions research.

Yi Quan, Yue-Bo Jia, Chen-Heng Wu, Qing-Ling Jia, Yong-Qi Chen, Zhi-Jian Gu, Jiang-Hong Ling

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastrointestinal surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yi QuanDepartment of Gastroenterology, Shuguang Affiliated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China.
Yue-Bo JiaDepartment of Gastroenterology, Shuguang Affiliated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China.
Chen-Heng WuDepartment of Gastroenterology, Shuguang Affiliated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China.
Qing-Ling JiaDepartment of Gastroenterology, Shuguang Affiliated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China.
Yong-Qi ChenDepartment of Pathology, Shuguang Affiliated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China.
Zhi-Jian GuDepartment of Gastroenterology, Shuguang Affiliated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China.
Jiang-Hong LingDepartment of Gastroenterology, Shuguang Affiliated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China. 459183870@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precancerous lesions of gastric cancer (PLGC) are crucial for the progression to gastric cancer, and early intervention in PLGC is pivotal in preventing its development into gastric cancer. In order to illustrate the molecular mechanisms underlying PLGC and the roles of associated genes within these lesions, genetically engineered mouse models (GEMMs) have been developed. We systematically summarize the current GEMMs, and highlight the principal pathological mechanisms involved, including gastrin/gastric acid balance, inflammatory factors, the interplay between cancer-promoting and cancer-suppressing genes, and apoptotic pathways. We further discuss the mechanisms involved in the existing GEMMs of PLGC.

Indexed as

Atrophic gastritisDysplasiaGenetically engineered miceIntestinal metaplasiaPathogenesisPrecancerous lesions of gastric cancer

Identifiers

PMID40740928
PMCPMC12305277

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.