ReviewWorld journal of gastrointestinal surgery2025
Association between hereditary spherocytosis and gallstone disease: Pathophysiology, diagnosis, and management.
Review in World journal of gastrointestinal surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hereditary spherocytosis (HS), a common inherited hemolytic anemia, is characterized by red blood cell membrane protein defects leading to chronic hemolysis. This condition significantly predisposes patients to gallstone disease, including both gallbladder and bile duct stones, due to excessive bilirubin production from hemolysis. Gallstones in HS patients, primarily composed of bilirubin, can lead to complications such as cholecystitis, cholangitis, and obstructive jaundice. This review provides a comprehensive landscape of the pathophysiological mechanisms linking HS to gallstone formation, emphasizing the roles of hemolysis, bile composition, and genetic factors. It also discusses the clinical manifestations of gallstone disease in HS, including recurrent jaundice and biliary obstruction, and highlights the diagnostic value of imaging modalities such as ultrasonography and magnetic resonance cholangiopancreatography. Furthermore, current management strategies, including splenectomy, cholecystectomy, and endoscopic approaches for bile duct stones, are examined in the context of HS. By synthesizing existing knowledge, this review aims to provide insights into improving the diagnosis, prevention, and treatment of gallstone disease in patients with HS, while identifying gaps for future research.
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