ArticleFrontiers in oncology2025
Radiotherapy improves survival in HER2-positive breast cancer with lung metastases: a retrospective study with artificial intelligence-based prognostic modeling.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Application of PI3K inhibitors in breast cancer treatment: a clinical trial landscape analysis based on clinical trial databases and registries.Frontiers in oncology · 2026Pooled it
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Human epidermal growth factor receptor 2 (HER2)-positive breast cancer is an aggressive subtype with a high risk of distant metastasis, particularly to the lungs. While systemic therapies have improved outcomes, the role of radiotherapy (RT) in the management of lung metastases remains uncertain. Methods: This retrospective study analyzed 248 HER2-positive breast cancer patients with lung metastases treated at two institutions between 2006 and 2021. Propensity score matching (PSM) was used to balance baseline characteristics between the RT and non-RT groups. Overall survival (OS) was assessed using Kaplan-Meier curves and Cox regression. A least absolute shrinkage and selection operator (LASSO)-Cox model was developed to identify prognostic factors, and its performance was evaluated using risk score visualization, receiver operating characteristic (ROC) analysis, and decision curve analysis (DCA). Results: RT significantly improved median OS both before (50.4 vs. 34.0 months, p < 0.001) and after PSM (51.5 vs. 32.3 months, p < 0.001). LASSO-Cox analysis confirmed RT as an independent prognostic factor. The predictive model demonstrated good discrimination (1- and 3-year AUCs of 0.716 and 0.722, respectively) and clinical utility by DCA. Conclusion: RT offers a significant survival benefit in HER2-positive breast cancer patients with lung metastases. AI-based modeling enhances prognostic accuracy and supports personalized treatment decisions.
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