Evidence map›Paper›PMID 40740789›Full record

ArticleFrontiers in immunology2025

Protection against prolonged pneumococcal infection involves structural changes in C-reactive protein and subsequent binding to both phosphocholine and amyloids on the bacterial surface.

Alok Agrawal, Donald N Ngwa, J Paul Simons, Sanjay K Singh

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alok AgrawalDepartment of Biomedical Sciences, College of Medicine, East Tennessee State University, Johnson City, TN, United States.
Donald N NgwaDepartment of Biomedical Sciences, College of Medicine, East Tennessee State University, Johnson City, TN, United States.
J Paul SimonsCentre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London, United Kingdom.
Sanjay K SinghDepartment of Biomedical Sciences, College of Medicine, East Tennessee State University, Johnson City, TN, United States.

Funding

Complement-mediated anti-pneumococcal functions of C-reactive proteinR01AI151561 · NIAID · EAST TENNESSEE STATE UNIVERSITY · PI SINGH, SANJAY KUMAR · 2020 to 2024
$1.9M
NIAID NIH HHS R01 AI151561
6 · The paper itself

Abstract

C-reactive protein (CRP) protects mice during the initial stages of

Indexed as

AmyloidC-Reactive ProteinPhosphorylcholinePneumococcal InfectionsStreptococcus pneumoniaeAnimalsFemaleMaleMiceMice, Inbred C57BLMice, KnockoutProtein BindingAmyloidC-Reactive ProteinPhosphorylcholinebacterial amyloidscomplement evasionC-reactive proteinserum amyloid P componentStreptococcus pneumoniae

Identifiers

PMID40740789
PMCPMC12307162

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.