ReviewFrontiers in immunology2025
Lymphoid stroma in all its states.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stromal cells are found in all tissues of the body. Among them, lymphoid stromal cells (LSCs) correspond to the cell subsets found in secondary and tertiary lymphoid organs. LSC heterogeneity has been characterized in depth in mice based on cell-fate mapping, high-resolution imaging and single-cell RNAseq analysis, and more recently in humans despite the difficulty of accessing these rare cell populations. At steady-state, LSCs organize discrete anatomical niches in lymphoid organs and orchestrate adaptive immune response. Studies of LSCs at the single cell level have identified a wide role for these cells in various pathological conditions, including solid tumors, autoimmune diseases, and lymphomas. In this review, we will discuss the diversity and plasticity of LSCs and LSC-like cells as well as their functions in pathological settings, with a focus on cancer and autoimmune diseases. Altogether, it highlights the importance of increasing our understanding of these cells, to use them as a target for novel therapeutic strategies.
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