ArticleKidney medicine2025
Effects of Podocyte Foot Process Effacement on Kidney Prognosis and Response to Immunosuppressive Therapy in IgA Nephropathy.
Article in Kidney medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Correlation of foot process effacement with clinicopathological features and short-term prognosis in IgA nephropathy.Annals of medicine · 2026Article
- Segmental Glomerulosclerosis Subclassification in the Oxford Classification System (MEST-C) Improves the International IgA Nephropathy Prediction Tool.Journal of clinical medicine · 2026Article
- Patterns of Glomerular Injury: Histopathological Classification and Clinical Correlation.Cureus · 2025Review
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Authors and funding
9 authors.
Funding
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Abstract
Rationale & Objective: Recent studies have proposed that podocyte lesions within segmental glomerulosclerosis (S1) lesions are associated with kidney prognosis in immunoglobulin A nephropathy (IgAN). However, there is a lack of research exploring the effect of podocyte lesions through electron microscopy, which is currently regarded as the best power tool for evaluating podocyte injury, on kidney prognosis and response to immunosuppressive therapy (IST). Study Design: An observational cohort study. Setting & Participants: Total of 976 patients with IgAN and at least 12 months of follow-up at Peking University First Hospital. Exposure: Different foot process effacement (FPE) severity evaluated by electron microscopy: mild: <50%, moderate: 50%-74%, and severe: ≥75%. Outcome: A composite kidney outcome of a 50% reduction in the estimated glomerular filtration rate or end-stage kidney disease. Analytical Approach: Cox proportional hazard models. Results: Moderate and severe FPE were independent risk factors for kidney outcome in overall cohort (severe: HR, 1.85; 95% CI, 1.22-2.80; Limitations: A single-center observational study, selection bias, and unmeasured confounders. Conclusions: Moderate and severe FPE were independent risk factors affecting kidney prognosis in patients with IgAN. Podocyte injury evaluated by electron microscopy had important clinical value in IgA nephropathy.
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