Evidence map›Paper›PMID 40740682›Full record

ArticleEMI. Animal & environment2025

Pathogenesis of Chapare virus in cynomolgus macaques.

Dylan M Johnson, Courtney Woolsey, Krystle N Agans, Viktoriya Borisevich, Abhishek N Prasad, Daniel J Deer, Natalie S Dobias, Karla A Fenton, Robert W Cross, Thomas W Geisbert

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMI. Animal & environment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dylan M JohnsonGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.ORCID https://orcid.org/0000-0002-3630-0588
Courtney WoolseyGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.ORCID https://orcid.org/0000-0003-3389-0137
Krystle N AgansGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.ORCID https://orcid.org/0000-0002-7319-6935
Viktoriya BorisevichGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
Abhishek N PrasadGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.ORCID https://orcid.org/0000-0002-4147-2077
Daniel J DeerGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.ORCID https://orcid.org/0009-0005-4744-8560
Natalie S DobiasGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.ORCID https://orcid.org/0009-0000-7352-5885
Karla A FentonGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
Robert W CrossGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.ORCID https://orcid.org/0000-0001-7718-1522
Thomas W GeisbertGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.ORCID https://orcid.org/0000-0003-0858-1877

Funding

Regulatory Compliance Core - Galveston National Laboratory BSL4 OperationsUC7AI094660 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Thomas Gary Ksiazek · 2011 to 2026
$208.8M
NIAID NIH HHS UC7 AI094660
6 · The paper itself

Abstract

Chapare virus (CHAPV) is an emerging New World arenavirus that is the causative agent of Chapare haemorrhagic fever (CHHF) responsible for recent outbreaks with alarmingly high case fatality rates in Bolivia near the Brazilian border. Here, we describe a nonhuman primate (NHP) model of CHHF infection which represents an essential tool to understand this emerging biological threat agent. Cynomolgus macaques challenged intravenously with CHAPV develop clinical disease, which recapitulates several key features of human CHHF. All subjects lost weight and had clinical scores following the CHAPV challenge. Notably, one of four NHPs developed a lethal disease with viral hepatitis and haemorrhagic features. Clinical chemistry and haematology revealed leukopoenia, anaemia, thrombocytopenia, and increased transaminase levels. In all four subjects, viremia was detectable for the first week following the challenge and viral RNA was detectable in serum and many tissues persisting 35 days post-challenge. Several medical countermeasures (MCM) have efficacy against CHAPV infection

Indexed as

ArenavirusChapare virusnatural history studyNew World Arenavirusnonhuman primate infection modelviral haemorrhagic fevers

Identifiers

PMID40740682
PMCPMC12306676

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.