ArticleJournal of human reproductive sciences
Novel SUN5 Mutation Associated with Acephalic Spermatozoa Syndrome: A Cross-sectional Study.
Article in Journal of human reproductive sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Background: The Aim: This study aims to evaluate the genetic variants of all exons of the Settings and Design: This cross-sectional study was conducted on 10 infertile men with ASS as a case group and 10 men with normal spermogram as a control group referred to the Royan institute between 2015 and 2020. Materials and Methods: Polymerase chain reaction and Sanger sequencing were performed on DNA extracted from patients' peripheral blood. In addition, immunocytochemistry and western blotting were accomplished to evaluate the SUN5 protein expression in the patient carrying a distinct exonic variation. Statistical Analysis Used: No statistical analysis was needed to be done in this survey. Results: Sequencing outcomes represented one homozygous missense mutation (c.1073G>A [p.Arg358Gln]) in exon 13 of the Conclusion: Based on current results, it could be concluded that c.1073G>A detected mutations in the
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