ArticleImaging neuroscience (Cambridge, Mass.)2024
The tip of the iceberg: A call to embrace anti-localizationism in human neuroscience research.
Article in Imaging neuroscience (Cambridge, Mass.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed.
- Comparing neuromodulation targets to reduce cigarette craving and withdrawal: a randomized clinical trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Trial
- Brain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease.Nature communications · 2026Article
- When Music Loses Its Pleasure: Hippocampal Cingulum White Matter as a Structural Mediator of Musical Reward Decline in Aging.bioRxiv : the preprint server for biology · 2026Article
- Selectivity for high-level language processing is highly localized in individual brains.bioRxiv : the preprint server for biology · 2026Article
- Feature selection leads to divergent neurobiological interpretations of brain-based machine learning biomarkers.Nature human behaviour · 2026Article
- Intensity-dependent topographical expansion of sensory representations.bioRxiv : the preprint server for biology · 2026Article
- Effect sizes in human functional neuroimaging.Research square · 2026Article
- The Hidden Landscape of Missed Effects in Human Functional Neuroimaging.bioRxiv : the preprint server for biology · 2026Article
- Manifold lateralisation and variability in the language connectome at 7T.Research square · 2026Article
- One Earth + One Health: An Agile, Evolutionary, System-of-Systems Convergence Paradigm.Environmental science & technology · 2026Review
- Cognition, but not affect, rests upon a segregated intrinsic network architecture.bioRxiv : the preprint server for biology · 2026Article
- Rethinking the centrality of brain areas in understanding functional organization.Nature neuroscience · 2026Review
- The average does not represent the individual: White matter variability across the brain, across the population, and across the lifespan.Research square · 2026Article
- Neural activity flows through cortical subnetworks during speech production.Cell reports · 2026Article
- The need for cultural sensitivity and epistemic justice in applying neuroscience advances in the Global South.Frontiers in human neuroscience · 2026Article
- Overlooked features lead to divergent neurobiological interpretations of brain-based machine learning biomarkers.bioRxiv : the preprint server for biology · 2025Article
- Identifying subtypes based on environmental and neurobiological risk and resilience factors of postpartum maternal mental health.Translational psychiatry · 2025Article
- Variation in moment-to-moment brain state engagement follows a consistent trajectory during development.Neuron · 2025Article
- Multivariate patterns linking brain microstructure to temperament and behavior in adolescent eating disorders.Molecular psychiatry · 2025Article
- Laughter as a Subject and a Tool for Interdisciplinary Investigations in Philosophy and Neuroscience.The European journal of neuroscience · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Human neuroscience research remains largely preoccupied with mapping distinct brain areas to complex psychological processes and features of mental health disorders. While this reductionist and localizationist perspective has resulted in several substantive contributions to the field, it has long been viewed as only a piece of the puzzle. Emerging evidence now empirically demonstrates how a historical reliance on localizationist techniques may underlie recent challenges to reproducibility and translation in human neuroscience. To advance discovery, we must collectively better incorporate complex systems and machine-learning approaches that better capture the multidimensional, dynamic, and interacting nature of the brain. Moreover, we must begin to contend with how to best integrate complementary modalities beyond the brain to better understand complex mental processes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.