Evidence map›Paper›PMID 40740498›Full record

ArticleiScience2025

Desmosomal cadherin tension loss in pemphigus vulgaris mediated by the inhibition of active RhoA at cell-cell adhesions.

Xiaowei Jin, Jordan Rosenbohm, Eunju Kim, Bahareh Tajvidi Safa, Amir Ostadi Moghaddam, Kristina Seiffert-Sinha, Merced Leiker, Elijah Jones, Haiwei Zhai, Sindora R Baddam and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Xiaowei JinDepartment of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Jordan RosenbohmDepartment of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Eunju KimDepartment of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Bahareh Tajvidi SafaDepartment of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Amir Ostadi MoghaddamDepartment of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Kristina Seiffert-SinhaDepartment of Dermatology, University at Buffalo, Buffalo, NY 14203, USA.
Merced LeikerDepartment of Dermatology, University at Buffalo, Buffalo, NY 14203, USA.
Elijah JonesDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI 48823, USA.
Haiwei ZhaiDepartment of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Sindora R BaddamDepartment of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA.
Grayson MinnickDepartment of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Yucheng HuoSchool of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798, Republic of Singapore.
James K WahlDepartment of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, MO 64108, USA.
Fanben MengDepartment of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Changjin HuangSchool of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798, Republic of Singapore.
Jung Yul LimDepartment of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Daniel E ConwayDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA.
Animesh A SinhaDepartment of Dermatology, University at Buffalo, Buffalo, NY 14203, USA.
Ruiguo YangDepartment of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.

Funding

The role of stress in the fetal origin of obesity and metabolic dysfunctionP20GM104320 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI ZEMPLENI, JANOS · 2014 to 2024
$24.9M
Targeted mass spectrometry approaches to understand CART processing and recepter interactionsP20GM113126 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI GUO, JIANTAO · 2016 to 2025
$20.8M
Cell junction and nuclear forces as mediators of epithelial cell homeostasisR35GM119617 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI Daniel E Conway · 2016 to 2026
$4.5M
Direct and Quantitative Probing of Desmosome MechanotransductionR35GM150623 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI Ruiguo Yang · 2023 to 2026
$1.5M
Regulation of Desmosome Dynamics by Plakophilin PalmitoylationR15AR072959 · NIAMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WAHL, JAMES K · 2018 to 2018
$457k
Measurement of Mechanical Tension Across DesmosomesR03AR068096 · NIAMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI CONWAY, DANIEL E · 2016 to 2018
$212k
NIAMS NIH HHS R03 AR068096NIAMS NIH HHS R15 AR072959NIGMS NIH HHS P20 GM104320NIGMS NIH HHS P20 GM113126NIGMS NIH HHS R35 GM119617NIGMS NIH HHS R35 GM150623
6 · The paper itself

Abstract

Autoantibody binding to keratinocyte surface antigens, primarily desmoglein 3 (Dsg3) in the desmosome, leads to dissociation of cell-cell adhesions in pemphigus vulgaris. Much of the biophysical transformations after antibody binding remain underexplored. It is unclear how tensions in desmosomes and cell-cell adhesion structures change in response to antibodies, and how the altered tensional states translate to cellular responses. Here, using fluorescence resonance energy transfer-based tension sensors and traction force microscopy, we observed tension loss at Dsg3 and the entire cell-cell adhesion after antibody binding, along with potentially compensatory increase in junctional traction force at cell-extracellular matrix adhesions. Our data also indicate that this tension loss is mediated by RhoA inhibition at cell-cell contacts and can be partially restored by altering cell contractility. Collectively, these findings shed light on the biophysical mechanisms governing cell-cell interactions under autoimmune conditions, and may lead to therapies aimed at restoring tensional balance at cell-cell adhesions.

Indexed as

Cell biologyFunctional aspects of cell biologyOrganizational aspects of cell biology

Identifiers

PMID40740498
PMCPMC12307676

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.