Evidence map›Paper›PMID 40740495›Full record

ArticleiScience2025

lncRNA ADEPTR loss-of-function elicits sex-specific behavioral and spine deficits.

Kaushik Chanda, Jackson P Carter, Hirofumi Nishizono, Bindu L Raveendra, Alicia Brantley, Eddie Grinman, Isabel Espadas, Sebastian Lozano-Villada, Jenna Lynne Wingfield, Grace Wagner and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. The Long Non-coding RNA Landscape of Endurance Exercise Training.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kaushik ChandaDepartment of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458, USA.
Jackson P CarterDepartment of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458, USA.
Hirofumi NishizonoMax Planck Florida Institute, 1 Max Planck Way, Jupiter, FL 33458, USA.
Bindu L RaveendraDepartment of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458, USA.
Alicia BrantleyMouse Behavior Core, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458, USA.
Eddie GrinmanDepartment of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458, USA.
Isabel EspadasDepartment of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458, USA.
Sebastian Lozano-VilladaDepartment of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458, USA.
Jenna Lynne WingfieldDepartment of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458, USA.
Grace WagnerAnimal Resources Center, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458, USA.
Amy PetersonAnimal Resources Center, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458, USA.
Ryohei YasudaMax Planck Florida Institute, 1 Max Planck Way, Jupiter, FL 33458, USA.
Sathyanarayanan V PuthanveettilDepartment of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458, USA.

Funding

Transcriptomic Mechanisms of Formation and Persistence of Synapse Specific Long-Term MemoryR01MH119541 · NIMH · UNIVERSITY OF FLORIDA · PI PUTHANVEETTIL, SATHYA · 2019 to 2023
$2.7M
Novel role of mitotic kinesin KIF11 in structural plasticity and memoryF32MH131420 · NIMH · UNIVERSITY OF FLORIDA · PI WINGFIELD, JENNA LYNNE · 2022 to 2023
$139k
NIMH NIH HHS F32 MH131420NIMH NIH HHS R01 MH119541
6 · The paper itself

Abstract

Activity-dependent neuronal changes are critical for learning and memory, but the role of long noncoding RNAs (lncRNAs) in these processes is under active investigation. In this study we investigated ADEPTR, a dendritically localized, cAMP-modulated lncRNA essential for synapse morphology. Using two mouse models-one with ADEPTR deletion (L-ADEPTR) and another lacking its protein interaction domain (S-ADEPTR)-we examined sex-specific effects on behavior and neuronal architecture. Behavioral tests showed reduced anxiety in S-ADEPTR adult male mice, with no learning or memory deficits in either model. Neuronal cultures and brain samples from various developmental stages revealed morphological impairments in both sexes. Notably, L-ADEPTR female mice had fewer thin spines in the hippocampal CA1 region at postnatal day 42. Despite these structural deficits, increased expression of plasticity-related genes BDNF and cFOS in the cortex and hippocampus suggests compensatory mechanisms preserve cognitive function. These findings highlight a sex-specific role for ADEPTR in regulating neuronal structure and anxiety-related behaviors.

Indexed as

Molecular biologyNeuroscience

Identifiers

PMID40740495
PMCPMC12307743

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.