ArticleiScience2025
HHV-6 and EBV reactivation in relapsing remitting multiple sclerosis: Disability, progression, and inflammation links.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Review
- Uncovering the dynamics of extracellular vesicle microRNA trafficking in multiple sclerosis: delivery, diversion and retention.Extracellular vesicles and circulating nucleic acids · 2026Review
- Neurosenescence, inflammaging and neuroinflammation in neurodegenerative disorders.Frontiers in aging · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reactivation of human herpesvirus 6 (HHV-6) and Epstein-Barr virus (EBV) is observed in multiple sclerosis (MS). This study investigates immunoglobulins (Ig)G, IgM, and IgA responses to EBV nuclear antigen EBNA (peptide 386-405), HHV-6 (peptide 300-322) and EBV (peptide 243-268) deoxyuridine-triphosphatase (dUTPase), and different immune profiles in 58 patients with relapsing remitting MS (RRMS) compared to 60 healthy controls. IgA/IgG/IgM were measured utilizing enzyme-linked immunosorbent assays, and cytokines, chemokines, and growth factors utilizing multiplex immunoassays. RRMS patients showed significantly increased IgG, IgA, and IgM responses to all three viral antigens. IgG and IgM to HHV-6 dUTPase discriminated RRMS patients from controls with 91.5% accuracy. Neural network analysis combining EBV-dUTPase antibodies and immune profiles yielded 97.1% predictive accuracy. IgG/IgM responses to dUTPases correlated with Expanded Disability Status Scale/MS Severity Score and aberrations in M1 macrophage, Th17 profiles, and overall immune activation. HHV-6 and EBV reactivation contribute to RRMS through cytokine-driven immune activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.