Evidence map›Paper›PMID 40740433›Full record

ArticleBrain communications2025

CSF and blood neuronal injury biomarkers in spinal bulbar muscular atrophy and amyotrophic lateral sclerosis 4.

Pashtun Shahim, Abdullah AlQahtani, Angela D Kokkinis, Narjis Kazmi, Marie Ezuma-Ngwu, Jahan Misra, George Harmison, Nicole Benoit, Melina Jones, Elizabeth Howe and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Pashtun ShahimNeurogenetics Branch, National Institutes of Neurological Disorders and Stroke, NIH, 35 Convent Drive, Bethesda, MD 20814, USA.
Abdullah AlQahtaniNeurogenetics Branch, National Institutes of Neurological Disorders and Stroke, NIH, 35 Convent Drive, Bethesda, MD 20814, USA.
Angela D KokkinisNeurogenetics Branch, National Institutes of Neurological Disorders and Stroke, NIH, 35 Convent Drive, Bethesda, MD 20814, USA.
Narjis KazmiNeurogenetics Branch, National Institutes of Neurological Disorders and Stroke, NIH, 35 Convent Drive, Bethesda, MD 20814, USA.
Marie Ezuma-NgwuNeurogenetics Branch, National Institutes of Neurological Disorders and Stroke, NIH, 35 Convent Drive, Bethesda, MD 20814, USA.
Jahan MisraNeurogenetics Branch, National Institutes of Neurological Disorders and Stroke, NIH, 35 Convent Drive, Bethesda, MD 20814, USA.
George HarmisonNeurogenetics Branch, National Institutes of Neurological Disorders and Stroke, NIH, 35 Convent Drive, Bethesda, MD 20814, USA.
Nicole BenoitBiospecimen Core, National Institutes of Neurological Disorders and Stroke, NIH, 35 Convent Drive, Bethesda, MD 20814, USA.
Melina JonesBiospecimen Core, National Institutes of Neurological Disorders and Stroke, NIH, 35 Convent Drive, Bethesda, MD 20814, USA.
Elizabeth HoweNeurogenetics Branch, National Institutes of Neurological Disorders and Stroke, NIH, 35 Convent Drive, Bethesda, MD 20814, USA.
Alice B SchindlerNeurogenetics Branch, National Institutes of Neurological Disorders and Stroke, NIH, 35 Convent Drive, Bethesda, MD 20814, USA.
Galen O JoeRehabilitation Medicine Department, Clinical Center, NIH, Bethesda, MD 20892, USA.
Christopher GrunseichNeurogenetics Branch, National Institutes of Neurological Disorders and Stroke, NIH, 35 Convent Drive, Bethesda, MD 20814, USA.ORCID https://orcid.org/0000-0003-4994-2472

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal and bulbar muscular atrophy (SBMA) and amyotrophic lateral sclerosis 4 (ALS4) are two forms of motor neuron disease characterized by clinically slow disease progression. Based on the current limited human studies, the contribution of central nervous neurodegeneration to these diseases and the rate of clinical progression is unclear. Neuronal proteins glial fibrillary acidic protein (GFAP), neurofilament light (NfL) chain, or Total-tau measured in either cerebrospinal fluid or blood could serve as sensitive markers of neurodegeneration. We studied 56 adult participants (32 SBMA, 7 ALS4, and 17 controls) who were enrolled at the National Institutes of Health, of whom 22 (10 SBMA, 7 ALS4, and 5 controls) underwent paired CSF and serum sampling, and of whom 6 participants were assessed longitudinally up to 24 months from initial visit. An additional 7 controls completed CSF sampling only. CSF GFAP, NfL chain, and Total-tau correlated with corresponding levels in serum (

Indexed as

ALS4CSFGFAPNfLSBMA

Identifiers

PMID40740433
PMCPMC12308280

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.