ReviewFrontiers in public health2025
Advances and challenges in poliomyelitis vaccines: a comprehensive review of development, production, and global deployment.
Review in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Review
- Article
- Towards Global HPV Eradication: Single-Dose HPV Vaccination vs. Pseudoscience.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Article
- Frequency and correlates of non-receipt of age-appropriate vaccination among children aged 6-35 months with medically attended diarrhea: Findings from the Enterics for Global Health (EFGH) Shigella study, 2022-2024.PLOS global public health · 2026Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Poliomyelitis has been a significant global health challenge for centuries. Since the launch of the Global Polio Eradication Initiative (GPEI) in 1988, remarkable progress has been achieved, with wild poliovirus (WPV) cases reduced by over 99%. However, challenges persist, including endemic transmission in conflict zones, the emergence of vaccine-derived polioviruses (VDPVs), and the complex logistics of vaccine production and distribution. This review synthesized the latest advancements in poliovirus vaccine development, production, and global deployment. Specific topics include the historical milestones of inactivated poliovirus vaccine (IPV) and oral poliovirus vaccine (OPV), innovations in next-generation vaccines such as novel OPV (nOPV2), intradermal IPV (IIPV), virus-like particle (VLP) vaccines, and mRNA vaccines, as well as critical considerations in manufacturing, quality control, and regulatory compliance. We also examined global strategies for vaccination campaigns, cold chain management, and eradication-endgame planning, alongside emerging challenges like VDPVs outbreaks, funding constraints, and geopolitical barriers. The significance of sustained global cooperation, equitable resource allocation, and technological advancement are essential to achieving a polio-free world, with the integration of scientific innovation with public health strategies. The lessons and insights presented herein inform polio eradication efforts, providing a blueprint for future disease eradication initiatives. The importance of resilience, adaptability, and community engagement was also emphasized for global health governance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.