SynthesisFrontiers in cellular and infection microbiology2025
Clinical features of patients with fungal infections caused by CARD9 deficiency: a literature review of case reports.
Synthesis in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- CARD9 Mutations in Patients with Fungal Infections: A Comprehensive Literature Review.Mycopathologia · 2026Pooled it
- A novel linker region truncating variant in BCL10 underlies a leaky immunodeficiency phenotype.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Intracranial infections ofFrontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caspase recruitment domain containing protein 9 (CARD9) deficiency is an autosomal-recessive primary immunodeficiency disorder, undermines the body's capacity to combat fungal infections. In recent years, the number of reported cases of fungal infections associated with CARD9 deficiency has been increasing. This study undertook a systematic review of case reports, incorporating 89 patients with CARD9 deficiency complicated by fungal infections. The findings demonstrated that the patient population predominantly consisted of young and middle-aged individuals (33.43 ± 19.12 years, range: 1-91), and the majority (52 patients, 58.43%) developed the disease during childhood or adolescence. Significant geographical variations were observed in the distribution of gene mutations. Specifically, the c.820dupG mutation was predominantly found in East Asia, while the c.865C>T mutation was primarily found North Africa. Regarding the clinical manifestations, the most frequently affected sites were the skin, central nervous system, and lymph nodes, and the principal fungal pathogens identified were
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Registered trials
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