ArticleFrontiers in microbiology2025
Revisiting phage tail spike architecture: evidence for undetected receptor-binding proteins in
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Innovative Applications of Artificial Intelligence in Bacteriophage Research: A New Chapter in Future Medicine.Microorganisms · 2026Review
- F-Type Pyocin Versus Phage λ Tail: Conserved Hub, Divergent Fibers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Phage Φ170 biocontrol of multidrug-resistantMicrobiology spectrum · 2026Article
- Genome-based taxonomic classification ofFrontiers in microbiology · 2026Article
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Authors and funding
7 authors.
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Abstract
Introduction: Bacteriophages, viruses that infect bacterial cells, have garnered renewed interest as potential therapeutic agents due to the growing threat of antibiotic resistance. Effective application of bacteriophages requires a comprehensive understanding of their structure and mechanisms of action. Recent advances in structural biology techniques, such as cryo-electron microscopy (Cryo-EM) and cryo-electron tomography (Cryo-ET), along with significant progress in genome sequencing and bioinformatics, have greatly enhanced our knowledge of bacteriophage biology. However, these techniques remain insufficient in some cases to fully resolve the structure and function of phage tail spikes and tail fibers. Methods: This study investigates the receptor-binding proteins (RBPs) of bacteriophages within the Results: Our findings indicate that phages from the genera Discussion: These results suggest that the analysed phages possess an additional, previously unidentified protein at the tip of the tail spike, which likely facilitates interaction with receptor proteins on the bacterial cell surface.
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